PF 04628935

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Cat.No. 6347 - PF 04628935 | C24H26ClN7OS | CAS No. 1383719-97-8
Description: Potent ghrelin receptor inverse agonist
Chemical Name: 1-[2-[[2-Chloro-4-(2H-1,2,3-triazol-2-yl)phenyl]methyl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)ethanone
Purity: ≥98% (HPLC)

Biological Activity

Potent ghrelin receptor inverse agonist (IC50 = 4.6 nM). Orally bioavailable and exhibits reasonable brain penetration.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 496.03
Formula C24H26ClN7OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1383719-97-8
PubChem ID 70682037
Smiles ClC1=C(CN2CC3(CCN(C(CC4=CN(C=C(C)S5)C5=N4)=O)CC3)C2)C=CC(N6N=CC=N6)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.8 50
ethanol 9.92 20

Preparing Stock Solutions

The following data is based on the product molecular weight 496.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.08 mL 20.16 mL
5 mM 0.4 mL 2.02 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References are publications that support the products' biological activity.

Kung et al (2012) Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor. Bioorg.Med.Chem.Lett. 22 5410 PMID: 22677316

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Keywords: PF 04628935, supplier, PF04628935, inverse, agonists, agonism, ghrelin, orally, bioavailable, potent, Ghrelin, Receptors, Ghrelin, Receptors, Tocris Bioscience

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