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Potent and selective DGAT-1 inhibitor (IC50 = 19 nM). Exhibits >1000-fold selectivity for DGAT-1 over DGAT-2, and no significant activity against a range of other enzymes, ion channels and receptors. Reduces plasma triglyceride levels in a rat lipid challenge model. Orally bioavailable.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 396.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.61 mL||63.06 mL||126.12 mL|
|1 mM||2.52 mL||12.61 mL||25.22 mL|
|2 mM||1.26 mL||6.31 mL||12.61 mL|
|10 mM||0.25 mL||1.26 mL||2.52 mL|
References are publications that support the biological activity of the product.
Dow et al (2011) Discovery of PF-04620110, a potent, selective, and orally bioavailable inhibitor of DGAT-1. ACS Med.Chem.Lett. 2 407 PMID: 24900321
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Keywords: PF 04620110, PF 04620110 supplier, PF04620110, potent, selective, orally, bioavailable, inhibitors, inhibits, DGAT-1, Diacylglycerol, acyltransferase, O-Acyltransferase, 5863, Tocris Bioscience
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