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Biological Activity for PF 04620110
PF 04620110 is a potent and selective DGAT-1 inhibitor (IC50 = 19 nM). Exhibits >1000-fold selectivity for DGAT-1 over DGAT-2, and no significant activity against a range of other enzymes, ion channels and receptors. Reduces plasma triglyceride levels in a rat lipid challenge model. Orally bioavailable.
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for PF 04620110
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PF 04620110
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PF 04620110
The following data is based on the product molecular weight 396.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.61 mL||63.06 mL||126.12 mL|
|1 mM||2.52 mL||12.61 mL||25.22 mL|
|2 mM||1.26 mL||6.31 mL||12.61 mL|
|10 mM||0.25 mL||1.26 mL||2.52 mL|
References for PF 04620110
References are publications that support the biological activity of the product.
Dow et al (2011) Discovery of PF-04620110, a potent, selective, and orally bioavailable inhibitor of DGAT-1. ACS Med.Chem.Lett. 2 407 PMID: 24900321
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Keywords: PF 04620110, PF 04620110 supplier, PF04620110, potent, selective, orally, bioavailable, inhibitors, inhibits, DGAT-1, Diacylglycerol, acyltransferase, O-Acyltransferase, 5863, Tocris Bioscience
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