Perhexiline maleate

Pricing Availability Delivery Time Qty
Cat.No. 5166 - Perhexiline maleate | C19H35N.C4H4O4 | CAS No. 6724-53-4
Description: Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor
Chemical Name: 2-(2,2-Dicyclohexylethyl)piperidine maleate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor. Inhibits palmitate oxidation in rat cardiomyocytes and increases cardiac efficiency in isolated rat hearts. Antianginal.

Technical Data

M. Wt 393.56
Formula C19H35N.C4H4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 6724-53-4
PubChem ID 5284439
InChI Key JDZOTSLZMQDFLG-BTJKTKAUSA-N
Smiles OC(\C=C/C(O)=O)=O.C1(CC(C3CCCCC3)C2CCCCC2)NCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.36 100
ethanol 7.87 20

Preparing Stock Solutions

The following data is based on the product molecular weight 393.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.7 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Kennedy et al (1996) Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone. Biochem.Pharmacol. 52 273 PMID: 8694852

Unger et al (2005) Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium. J.Cardiovasc.Pharmacol. 46 849 PMID: 16306812

Yin et al (2013) Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome. J.Mol.Cell.Cardiol. 55 27 PMID: 23277191


If you know of a relevant reference for Perhexiline maleate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Transferase Inhibitors

Keywords: Perhexiline maleate, Perhexiline maleate supplier, Carnitine, palmitoyltransferase-1/2, CPT1, CPT2, antianginal, cardiac, inhibits, inhibitors, Other, Transferases, 5166, Tocris Bioscience

Citations for Perhexiline maleate

Citations are publications that use Tocris products.

Currently there are no citations for Perhexiline maleate. Do you know of a great paper that uses Perhexiline maleate from Tocris? Please let us know.

Reviews for Perhexiline maleate

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Perhexiline maleate?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Filter by:


CPT1 antagonism on acute brain slices
By Anonymous on 01/10/2018
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: acute brain slice

Used as a second way to block CPT1 (etomoxir was the other blocker used). Both had the same effect, confirming the involvement of CPT1 in our assay.

30 minute pre-incubation, rapid effect


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells