Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor. Inhibits palmitate oxidation in rat cardiomyocytes and increases cardiac efficiency in isolated rat hearts. Antianginal.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 393.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.54 mL||12.7 mL||25.41 mL|
|5 mM||0.51 mL||2.54 mL||5.08 mL|
|10 mM||0.25 mL||1.27 mL||2.54 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
References are publications that support the biological activity of the product.
Kennedy et al (1996) Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone. Biochem.Pharmacol. 52 273 PMID: 8694852
Unger et al (2005) Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium. J.Cardiovasc.Pharmacol. 46 849 PMID: 16306812
Yin et al (2013) Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome. J.Mol.Cell.Cardiol. 55 27 PMID: 23277191
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Keywords: Perhexiline maleate, Perhexiline maleate supplier, Carnitine, palmitoyltransferase-1/2, CPT1, CPT2, antianginal, cardiac, inhibits, inhibitors, Other, Transferases, 5166, Tocris Bioscience
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Used as a second way to block CPT1 (etomoxir was the other blocker used). Both had the same effect, confirming the involvement of CPT1 in our assay.
30 minute pre-incubation, rapid effect
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