Perhexiline maleate

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Cat.No. 5166 - Perhexiline maleate | C19H35N.C4H4O4 | CAS No. 6724-53-4
Description: Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor
Chemical Name: 2-(2,2-Dicyclohexylethyl)piperidine maleate
Purity: ≥99% (HPLC)
Reviews (1)

Biological Activity

Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor. Inhibits palmitate oxidation in rat cardiomyocytes and increases cardiac efficiency in isolated rat hearts. Antianginal.

Technical Data

M. Wt 393.56
Formula C19H35N.C4H4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 6724-53-4
PubChem ID 5284439

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.36 100
ethanol 7.87 20

Preparing Stock Solutions

The following data is based on the product molecular weight 393.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.7 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Kennedy et al (1996) Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone. Biochem.Pharmacol. 52 273 PMID: 8694852

Unger et al (2005) Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium. J.Cardiovasc.Pharmacol. 46 849 PMID: 16306812

Yin et al (2013) Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome. J.Mol.Cell.Cardiol. 55 27 PMID: 23277191

If you know of a relevant reference for Perhexiline maleate, please let us know.

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Keywords: Perhexiline maleate, supplier, Carnitine, palmitoyltransferase-1/2, CPT1, CPT2, antianginal, cardiac, inhibits, inhibitors, Other, Transferases, Other, Transferases, Tocris Bioscience

Citations for Perhexiline maleate

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Reviews for Perhexiline maleate

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CPT1 antagonism on acute brain slices
By Anonymous on 01/10/2018
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: acute brain slice

Used as a second way to block CPT1 (etomoxir was the other blocker used). Both had the same effect, confirming the involvement of CPT1 in our assay.

30 minute pre-incubation, rapid effect

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