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Biological Activity for Perhexiline maleate
Perhexiline maleate is a carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor. Inhibits palmitate oxidation in rat cardiomyocytes and increases cardiac efficiency in isolated rat hearts. Antianginal.
Compound Libraries for Perhexiline maleate
Technical Data for Perhexiline maleate
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Perhexiline maleate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Perhexiline maleate
The following data is based on the product molecular weight 393.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.54 mL||12.7 mL||25.41 mL|
|5 mM||0.51 mL||2.54 mL||5.08 mL|
|10 mM||0.25 mL||1.27 mL||2.54 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
Product Datasheets for Perhexiline maleate
References for Perhexiline maleate
References are publications that support the biological activity of the product.
Kennedy et al (1996) Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiod. Biochem.Pharmacol. 52 273 PMID: 8694852
Unger et al (2005) Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium. J.Cardiovasc.Pharmacol. 46 849 PMID: 16306812
Yin et al (2013) Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome. J.Mol.Cell.Cardiol. 55 27 PMID: 23277191
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Keywords: Perhexiline maleate, Perhexiline maleate supplier, Carnitine, palmitoyltransferase-1/2, CPT1, CPT2, antianginal, cardiac, inhibits, inhibitors, Other, Transferases, 5166, Tocris Bioscience
1 Citation for Perhexiline maleate
Citations are publications that use Tocris products. Selected citations for Perhexiline maleate include:
Louis-Philippe et al (2020) Microglial metabolic flexibility supports immune surveillance of the brain parenchyma. Nat Commun 11 1559 PMID: 32214088
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Reviews for Perhexiline maleate
Average Rating: 5 (Based on 1 Review.)
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Used as a second way to block CPT1 (etomoxir was the other blocker used). Both had the same effect, confirming the involvement of CPT1 in our assay.
30 minute pre-incubation, rapid effect