Perhexiline maleate

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Cat.No. 5166 - Perhexiline maleate | C19H35N.C4H4O4 | CAS No. 6724-53-4
Description: Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor
Chemical Name: 2-(2,2-Dicyclohexylethyl)piperidine maleate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor. Inhibits palmitate oxidation in rat cardiomyocytes and increases cardiac efficiency in isolated rat hearts. Antianginal.

Technical Data

M. Wt 393.56
Formula C19H35N.C4H4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 6724-53-4
PubChem ID 5284439
InChI Key JDZOTSLZMQDFLG-BTJKTKAUSA-N
Smiles OC(\C=C/C(O)=O)=O.C1(CC(C3CCCCC3)C2CCCCC2)NCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.36 100
ethanol 7.87 20

Preparing Stock Solutions

The following data is based on the product molecular weight 393.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.7 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kennedy et al (1996) Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone. Biochem.Pharmacol. 52 273 PMID: 8694852

Unger et al (2005) Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium. J.Cardiovasc.Pharmacol. 46 849 PMID: 16306812

Yin et al (2013) Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome. J.Mol.Cell.Cardiol. 55 27 PMID: 23277191


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Keywords: Carnitine palmitoyltransferase-1/2 CPT1 CPT2 antianginal cardiac inhibits inhibitors Other Transferases

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