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Cat.No. 6394 - Peptide5 | Val-Asp-Cys-Phe-Leu-Ser-Arg-Pro-Thr-Glu-Lys-Thr | CAS No. 916977-43-0
Description: Connexin43 mimetic peptide

Biological Activity

Connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain.

Technical Data

M. Wt 1395.59
Formula C60H98N16O20S
Storage Store at -20°C
CAS Number 916977-43-0
PubChem ID 90693053
Smiles [H]N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1395.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.72 mL 3.58 mL 7.17 mL
5 mM 0.14 mL 0.72 mL 1.43 mL
10 mM 0.07 mL 0.36 mL 0.72 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

O'Carroll et al (2008) Connexin 43 mimetic peptides reduce swelling, astrogliosis and neuronal cell death after spinal cord injury. Cell.Commun.Adhes. 15 27 PMID: 18649176

Mao et al (2017) Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats. Exp.Brain.Res. 235 3033 PMID: 28725925

Kim et al (2017) Characterising the mode of action of extracellular Connexin43 channel mimetic peptides in an in vitro ischemia injury model. Biochem.Biophys.Acta. 1861 68 PMID: 27816754

Tonkin et al (2017) Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Exp.Neurol. 300 1 PMID: 29055716

If you know of a relevant reference for Peptide5, please let us know.

Keywords: Peptide5, supplier, Connexin43, mimetics, mimics, analgesic, Cx43, peptide5, Cell, Adhesion, Molecules, Gap, Channels, Cell, Adhesion, Molecules, Tocris Bioscience

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