Peptide5

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Cat.No. 6394 - Peptide5 | Val-Asp-Cys-Phe-Leu-Ser-Arg-Pro-Thr-Glu-Lys-Thr | CAS No. 916977-43-0
Description: Connexin43 mimetic peptide
Datasheet
Citations
Reviews
Literature

Biological Activity

Connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain.

Technical Data

M. Wt 1395.59
Formula C60H98N16O20S
Sequence VDCFLSRPTEKT
Storage Store at -20°C
CAS Number 916977-43-0
PubChem ID 90693053
InChI Key RJEAEIUDNCLZNN-VUZGFOMDSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in water

References

References are publications that support the biological activity of the product.

O'Carroll et al (2008) Connexin 43 mimetic peptides reduce swelling, astrogliosis and neuronal cell death after spinal cord injury. Cell.Commun.Adhes. 15 27 PMID: 18649176

Mao et al (2017) Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats. Exp.Brain.Res. 235 3033 PMID: 28725925

Kim et al (2017) Characterising the mode of action of extracellular Connexin43 channel mimetic peptides in an in vitro ischemia injury model. Biochem.Biophys.Acta. 1861 68 PMID: 27816754

Tonkin et al (2017) Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Exp.Neurol. 300 1 PMID: 29055716


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Keywords: Peptide5, Peptide5 supplier, Connexin43, mimetics, mimics, analgesic, Cx43, peptide5, Cell, Adhesion, Molecules, Gap, Channels, 6394, Tocris Bioscience

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