Discontinued Product

PEPA (Cat. No. 2929) has been withdrawn from sale for commercial reasons.
Description: Allosteric potentiator of AMPA receptor desensitization
Chemical Name: 2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide
Purity: ≥99% (HPLC)
Literature (5)

Biological Activity for PEPA

Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluA3/4 > GluA1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.

Technical Data for PEPA

M. Wt 402.44
Formula C16H16F2N2O4S2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 141286-78-4
PubChem ID 6603828
Smiles FC1=CC(SCCNS(C2=CC=CC=C2)(=O)=O)=CC(F)=C1OCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PEPA

References are publications that support the biological activity of the product.

Sekiguchi et al (1997) A novel allosteric potentiator of AMPA receptors: 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide. J.Neurosci. 17 5760 PMID: 9221774

Sekiguchi et al (2002) A desensitization-selective potentiator of AMPA-type glutamate receptors. Br.J.Pharmacol. 136 1033 PMID: 12145103

Sekiguchi et al (2001) The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment. Neuroreport 12 2974

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Keywords: PEPA, PEPA supplier, Allosteric, potentiator, AMPA, receptor, desensitization, desensitisation, Glutamate, Receptors, iGluR, Ionotropic, 2929, Tocris Bioscience

Citations for PEPA

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Currently there are no citations for PEPA.

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