PEN (rat)
Biological Activity
Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.
Technical Data
| M. Wt | 2301.62 |
| Formula | C102H169N27O33 |
| Sequence | AVDQDLGPEVPPENVLGALLRV |
| Storage | Store at -20°C |
| CAS Number | 569364-13-2 |
| Smiles | [H]N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in PBS (pH 7.4) |
Preparing Stock Solutions
The following data is based on the product molecular weight 2301.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.43 mL | 2.17 mL | 4.34 mL |
| 5 mM | 0.09 mL | 0.43 mL | 0.87 mL |
| 10 mM | 0.04 mL | 0.22 mL | 0.43 mL |
| 50 mM | 0.01 mL | 0.04 mL | 0.09 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Gomes et al (2016) Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci.Signal. 9 ra43 PMID: 27117253
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Keywords: PEN (rat), supplier, GPR83, agonists, agonism, neuropeptide, JP05, GPR72, glucocorticoid-induced, receptor, pro-SAAS, (221-242), GPR83, GPR83, Tocris Bioscience
Citations for PEN (rat)
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The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.
