PEN (human)

Discontinued Product

PEN (human) (Cat. No. 6307) has been withdrawn from sale for commercial reasons.
Description: GPR83 agonist
Alternative Names: pro-SAAS (221-242)
Literature (2)

Biological Activity for PEN (human)

PEN (human) is a endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.

Technical Data for PEN (human)

M. Wt 2215.49
Formula C97H159N27O32
Storage Store at -20°C
CAS Number 597578-70-6
PubChem ID 16139549
Smiles [H]N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PEN (human)

References are publications that support the biological activity of the product.

Gomes et al (2016) Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci.Signal 9 ra43 PMID: 27117253

Mack et al (2019) Neuropeptide PEN and its receptor GPR83: distribution, signaling, and regulation. ACS Chem Neurosci. 10 1884 PMID: 30726666

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Keywords: PEN (human), PEN (human) supplier, GPR83, agonists, agonism, neuropeptide, JP05, GPR72, glucocorticoid-induced, receptor, pro-SAAS, (221-242), 6307, Tocris Bioscience

Citations for PEN (human)

Citations are publications that use Tocris products.

Currently there are no citations for PEN (human).

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Gut Hormones Poster

Gut Hormones Poster

The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.