Pemoline

Discontinued Product

Pemoline (Cat. No. 3045) has been withdrawn from sale for commercial reasons.
Cat.No. 3045 - Pemoline | C9H8N2O2 | CAS No. 2152-34-3
Description: CNS stimulant, indirect monoamine agonist
Alternative Names: Phenoxazole, Phenylisohydantoin
Chemical Name: 2-Amino-5-phenyl-4(5H)-oxazolone
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Long-acting central stimulant that induces self-injurious behavior in rats. Acts as an indirect monoamine agonist.

Technical Data

M. Wt 176.17
Formula C9H8N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2152-34-3
PubChem ID 4723
InChI Key NRNCYVBFPDDJNE-UHFFFAOYSA-N
Smiles O=C1C(C2=CC=CC=C2)OC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

References

References are publications that support the biological activity of the product.

Mueller and Nyhan (1982) Pharmacologic control of pemoline induced self-injurious behavior in rats. Pharmacol.Biochem.Behav. 16 957 PMID: 6213967

Kies and Devine (2004) Self-injurious behaviour: a comparison of caffeine and pemoline models in rats. Pharmacol.Biochem.Behav. 79 587 PMID: 15582667

Muehlmann et al (2008) Pemoline (2-Amino-5-phenyl-1,3-oxazol-4-one)-induced self-injurious behavior: a rodent model of pharmacotherapeutic efficacy. J.Pharmacol.Exp.Ther. 324 214 PMID: 17925479

Keywords: Pemoline, Pemoline supplier, CNS, stimulant, indirect, monoamine, agonists, Dopaminergic, Dopamine, Receptors, Adrenergic, Compounds, Adrenoceptors, Serotonin, 5-HT-, 5-Hydroxytryptamine, Phenoxazole, Phenylisohydantoin, Dopaminergic-Related, Related, 5-HT-Related, 5-HT3, 3045, Tocris Bioscience

1 Citation for Pemoline

Citations are publications that use Tocris products. Selected citations for Pemoline include:

Jones et al (2015) Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior. Nat Neurosci 18 373 PMID: 25643294


Reviews for Pemoline

There are currently no reviews for this product. Be the first to review Pemoline and earn rewards!

Have you used Pemoline?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.