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Submit ReviewPemoline
Discontinued Product
Pemoline (Cat. No. 3045) has been withdrawn from sale for commercial reasons.
Description: CNS stimulant, indirect monoamine agonist
Alternative Names: Phenoxazole, Phenylisohydantoin
Chemical Name: 2-Amino-5-phenyl-4(5H)-oxazolone
Purity: ≥99% (HPLC)
Biological Activity for Pemoline
Long-acting central stimulant that induces self-injurious behavior in rats. Acts as an indirect monoamine agonist.
Technical Data for Pemoline
| M. Wt | 176.17 |
| Formula | C9H8N2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 2152-34-3 |
| PubChem ID | 4723 |
| InChI Key | NRNCYVBFPDDJNE-UHFFFAOYSA-N |
| Smiles | O=C1C(C2=CC=CC=C2)OC(N)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Pemoline
References for Pemoline
References are publications that support the biological activity of the product.
Mueller and Nyhan (1982) Pharmacologic control of pem. induced self-injurious behavior in rats. Pharmacol.Biochem.Behav. 16 957 PMID: 6213967
Kies and Devine (2004) Self-injurious behaviour: a comparison of caffeine and pem. models in rats. Pharmacol.Biochem.Behav. 79 587 PMID: 15582667
Muehlmann et al (2008) Pemoline (2-Amino-5-phenyl-1,3-oxazol-4-one)-induced self-injurious behavior: a rodent model of pharmacotherapeutic efficacy. J.Pharmacol.Exp.Ther. 324 214 PMID: 17925479
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Keywords: Pemoline, Pemoline supplier, CNS, stimulant, indirect, monoamine, agonists, Dopaminergic, Dopamine, Receptors, Adrenergic, Compounds, Adrenoceptors, Serotonin, 5-HT-, 5-Hydroxytryptamine, Phenoxazole, Phenylisohydantoin, Dopaminergic-Related, Related, 5-HT-Related, 5-HT3, 3045, Tocris Bioscience
1 Citation for Pemoline
Citations are publications that use Tocris products. Selected citations for Pemoline include:
Jones et al (2015) Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior. Nat Neurosci 18 373 PMID: 25643294
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.