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Cat.No. 3045 - Pemoline | C9H8N2O2 | CAS No. 2152-34-3
Description: CNS stimulant, indirect monoamine agonist
Alternative Names: Phenoxazole, Phenylisohydantoin
Chemical Name: 2-Amino-5-phenyl-4(5H)-oxazolone
Purity: ≥99% (HPLC)

Biological Activity

Long-acting central stimulant that induces self-injurious behavior in rats. Acts as an indirect monoamine agonist.

Technical Data

M. Wt 176.17
Formula C9H8N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2152-34-3
PubChem ID 4723
Smiles O=C1C(C2=CC=CC=C2)OC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 1.76 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 176.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.68 mL 28.38 mL 56.76 mL
5 mM 1.14 mL 5.68 mL 11.35 mL
10 mM 0.57 mL 2.84 mL 5.68 mL
50 mM 0.11 mL 0.57 mL 1.14 mL

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References are publications that support the products' biological activity.

Mueller and Nyhan (1982) Pharmacologic control of pemoline induced self-injurious behavior in rats. Pharmacol.Biochem.Behav. 16 957 PMID: 6213967

Kies and Devine (2004) Self-injurious behaviour: a comparison of caffeine and pemoline models in rats. Pharmacol.Biochem.Behav. 79 587 PMID: 15582667

Muehlmann et al (2008) Pemoline (2-Amino-5-phenyl-1,3-oxazol-4-one)-induced self-injurious behavior: a rodent model of pharmacotherapeutic efficacy. J.Pharmacol.Exp.Ther. 324 214 PMID: 17925479

If you know of a relevant reference for Pemoline, please let us know.

Keywords: Pemoline, supplier, CNS, stimulant, indirect, monoamine, agonists, Dopaminergic, Dopamine, Receptors, Adrenergic, Compounds, Adrenoceptors, Serotonin, 5-HT-, 5-Hydroxytryptamine, Phenoxazole, Phenylisohydantoin, Dopaminergic-Related, Adrenergic, Related, Compounds, 5-HT-Related, 5-HT3, Receptors, Dopaminergic-Related, Tocris Bioscience

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