PDZ1 Domain inhibitor peptide
Novel cyclic peptide that disrupts interaction between GluK2 (formally GluR6) and the postsynaptic density protein 95 (PSD-95). Competes with the C-terminus of GluK2 for binding to the PDZ1 domain of PSD-95. Inhibits clustering of kainate receptors.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
(Modifications: Ala-6 = β-Ala, Cyclized = Lys-3 - Ala-6))
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in 5% acetonitrile / water and to 4 mg/ml in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 819.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.22 mL||6.1 mL||12.2 mL|
|5 mM||0.24 mL||1.22 mL||2.44 mL|
|10 mM||0.12 mL||0.61 mL||1.22 mL|
|50 mM||0.02 mL||0.12 mL||0.24 mL|
References are publications that support the biological activity of the product.
Piserchio et al (2004) Targeting specific PDZ domains of PSD-95: structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem.Biol. 11 469 PMID: 15123241
If you know of a relevant reference for PDZ1 Domain inhibitor peptide, please let us know.
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Keywords: PDZ1 Domain inhibitor peptide, PDZ1 Domain inhibitor peptide supplier, Disrupts, interaction, between, GluR6, PSD-95, PDZ1, domain, Glutamate, Kainate, Receptors, iGluR, Ionotropic, GluK2, 2207, Tocris Bioscience
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