PDZ1 Domain inhibitor peptide

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Cat.No. 2207 - PDZ1 Domain inhibitor peptide | Tyr-Lys-cyclo(-Lys-Thr-Glu-β-Ala-)-Val | CAS No. 1315378-73-4
Description: Disrupts interaction between GluK2 and PSD-95 PDZ1 domain
Datasheet
Citations
Reviews
Literature

Biological Activity

Novel cyclic peptide that disrupts interaction between GluK2 (formally GluR6) and the postsynaptic density protein 95 (PSD-95). Competes with the C-terminus of GluK2 for binding to the PDZ1 domain of PSD-95. Inhibits clustering of kainate receptors.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M. Wt 819.95
Formula C38H61N9O11
Sequence YKKTEAV

(Modifications: Ala-6 = β-Ala, Cyclized = Lys-3 - Ala-6))

Storage Desiccate at -20°C
CAS Number 1315378-73-4
PubChem ID 90488746
InChI Key XXRRADBJCXMGOW-RMLJCASOSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in 5% acetonitrile / water and to 4 mg/ml in DMSO

References

References are publications that support the biological activity of the product.

Piserchio et al (2004) Targeting specific PDZ domains of PSD-95: structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem.Biol. 11 469 PMID: 15123241


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Keywords: PDZ1 Domain inhibitor peptide, PDZ1 Domain inhibitor peptide supplier, Disrupts, interaction, between, GluR6, PSD-95, PDZ1, domain, Glutamate, Kainate, Receptors, iGluR, Ionotropic, GluK2, 2207, Tocris Bioscience

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