PDZ1 Domain inhibitor peptide
Novel cyclic peptide that disrupts interaction between GluR6 and the postsynaptic density protein 95 (PSD-95). Competes with the C-terminus of GluR6 for binding to the PDZ1 domain of PSD-95. Inhibits clustering of kainate receptors.
(Modifications: Ala-6 = β-Ala, Cyclized = Lys-3 - Ala-6))
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in 5% acetonitrile / water and to 4 mg/ml in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 819.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.22 mL||6.1 mL||12.2 mL|
|5 mM||0.24 mL||1.22 mL||2.44 mL|
|10 mM||0.12 mL||0.61 mL||1.22 mL|
|50 mM||0.02 mL||0.12 mL||0.24 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Piserchio et al (2004) Targeting specific PDZ domains of PSD-95: structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem.Biol. 11 469 PMID: 15123241
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Keywords: Disrupts interaction between GluR6 PSD-95 PDZ1 domain Glutamate Kainate Receptors iGluR Ionotropic Kainate Receptors
Citations for PDZ1 Domain inhibitor peptide
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