PDZ1 Domain inhibitor peptide

Pricing Availability Delivery Time Qty
Cat.No. 2207 - PDZ1 Domain inhibitor peptide | Tyr-Lys-cyclo(-Lys-Thr-Glu-β-Ala-)-Val | CAS No. 1315378-73-4
Description: Disrupts interaction between GluR6 and PSD-95 PDZ1 domain
Datasheet
Citations
Literature

Biological Activity

Novel cyclic peptide that disrupts interaction between GluR6 and the postsynaptic density protein 95 (PSD-95). Competes with the C-terminus of GluR6 for binding to the PDZ1 domain of PSD-95. Inhibits clustering of kainate receptors.

Technical Data

M. Wt 819.95
Formula C38H61N9O11
Sequence YKKTEAV

(Modifications: Ala-6 = β-Ala, Cyclized = Lys-3 - Ala-6))

Storage Desiccate at -20°C
CAS Number 1315378-73-4
PubChem ID 90488746
InChI Key XXRRADBJCXMGOW-RMLJCASOSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 5% acetonitrile / water and to 4 mg/ml in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 819.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.22 mL 6.1 mL 12.2 mL
5 mM 0.24 mL 1.22 mL 2.44 mL
10 mM 0.12 mL 0.61 mL 1.22 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Piserchio et al (2004) Targeting specific PDZ domains of PSD-95: structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem.Biol. 11 469 PMID: 15123241


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Keywords: PDZ1 Domain inhibitor peptide, supplier, Disrupts, interaction, between, GluR6, PSD-95, PDZ1, domain, Glutamate, Kainate, Receptors, iGluR, Ionotropic, Kainate, Receptors, Kainate, Receptors, Tocris Bioscience

Citations for PDZ1 Domain inhibitor peptide

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Pathways for PDZ1 Domain inhibitor peptide

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