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Biological Activity for PDD 00031705
PDD 00031705 is a negative control for PDD 00017238 (Cat. No. 7007).
Technical Data for PDD 00031705
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PDD 00031705
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PDD 00031705
The following data is based on the product molecular weight 490.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||20.38 mL||101.91 mL||203.82 mL|
|0.5 mM||4.08 mL||20.38 mL||40.76 mL|
|1 mM||2.04 mL||10.19 mL||20.38 mL|
|5 mM||0.41 mL||2.04 mL||4.08 mL|
References for PDD 00031705
References are publications that support the biological activity of the product.
James et al (2016) First-in-class chemical probes against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to Olaparib. ACS Chem.Biol. 11 3179 PMID: 27689388
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Citations for PDD 00031705
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Epigenetics in Cancer Poster
Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.