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PDD 00017238 New
High affinity and potent PARG inhibitor (Kd = 3.09 nM; IC50 = 40 nM).
Negative control PDD 00031705 (Cat. No. 7009) also available.
Sold under license from Cancer Research Technology Ltd (Ximbio).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 476.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.02 mM||104.91 mL||524.56 mL||1049.12 mL|
|0.1 mM||20.98 mL||104.91 mL||209.82 mL|
|0.2 mM||10.49 mL||52.46 mL||104.91 mL|
|1 mM||2.1 mL||10.49 mL||20.98 mL|
References are publications that support the biological activity of the product.
James et al (2016) First-in-class chemical probes against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to Olaparib. ACS Chem.Biol. 11 3179 PMID: 27689388
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