PDD 00017238

Pricing Availability   Qty
Description: High affinity and potent PARG inhibitor
Chemical Name: 1-[(2,4-Dimethyl-5-thiazolyl)methyl]-2,3-dihydro-N-(1-methylcyclopropyl)-2-oxo-3-(1,2,4-thiadiazol-5-yl)-1H-benzimidazole-5-sulfonamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for PDD 00017238

PDD 00017238 is a high affinity and potent PARG inhibitor (Kd = 3.09 nM; IC50 = 40 nM).

Negative control PDD 00031705 (Cat. No. 7009) also available.

Licensing Information

Sold under license from Cancer Research Technology Ltd (Ximbio).

Technical Data for PDD 00017238

M. Wt 476.59
Formula C19H20N6O3S3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1952247-05-0
PubChem ID 121415983
Smiles CC1=NC(C)=C(S1)CN2C(N(C3=CC(S(=O)(NC4(CC4)C)=O)=CC=C23)C5=NC=NS5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PDD 00017238

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 0.95 2

Preparing Stock Solutions for PDD 00017238

The following data is based on the product molecular weight 476.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.02 mM 104.91 mL 524.56 mL 1049.12 mL
0.1 mM 20.98 mL 104.91 mL 209.82 mL
0.2 mM 10.49 mL 52.46 mL 104.91 mL
1 mM 2.1 mL 10.49 mL 20.98 mL

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References for PDD 00017238

References are publications that support the biological activity of the product.

James et al (2016) First-in-class chemical probes against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to Olaparib. ACS Chem.Biol. 11 3179 PMID: 27689388

If you know of a relevant reference for PDD 00017238, please let us know.

View Related Products by Product Action

View all Poly(ADP-ribose) Glycohydrolase Inhibitors

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Citations for PDD 00017238

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Literature in this Area

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Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.