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Biological Activity for PD 90780
PD 90780 is a a nonpeptide inhibitor of NGF binding to p75NTR (IC50 ~ 1 μM in CHO cells); binds NGF, not p75NTR. Affinity maybe altered by the presence of TrkA receptors. Neuroprotective.
Technical Data for PD 90780
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PD 90780
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|1eq. NaOH||7.25||20 with sonication|
Preparing Stock Solutions for PD 90780
The following data is based on the product molecular weight 362.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||13.8 mL||69 mL||137.99 mL|
|1 mM||2.76 mL||13.8 mL||27.6 mL|
|2 mM||1.38 mL||6.9 mL||13.8 mL|
|10 mM||0.28 mL||1.38 mL||2.76 mL|
References for PD 90780
References are publications that support the biological activity of the product.
Colquhoun et al (2004) Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J.Pharmacol.Exp.Ther. 310 505 PMID: 15051797
Eibl et al (2012) Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor. Neurochem.Int. 61 1266 PMID: 23103525
Longo et al (2008) Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol.Disord.Drug Targets 7 63 PMID: 18289033
If you know of a relevant reference for PD 90780, please let us know.
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Keywords: PD 90780, PD 90780 supplier, PD90780, nonpeptide, inhibitors, inhibits, of, NGF, binding, p75, receptor, TrkA, neuroprotective, nerve, growth, factors, Trk, Receptors, 5101, Tocris Bioscience
Citations for PD 90780
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease PosterUpdated
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.