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Submit ReviewPD 90780
Description: Inhibits NGF binding to p75NTR
Chemical Name: 7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid
Purity: ≥98% (HPLC)
Biological Activity
A nonpeptide inhibitor of NGF binding to p75NTR (IC50 ~ 1 μM in CHO cells); binds NGF, not p75NTR. Affinity maybe altered by the presence of TrkA receptors. Neuroprotective.
Technical Data
| M. Wt | 362.34 |
| Formula | C19H14N4O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 77422-99-2 |
| PubChem ID | 9885305 |
| InChI Key | IAZAGXDMMVWYKF-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=CC=C4)NC1=CC=C3C(C(N2C(N3C)=CC(C(O)=O)=N2)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 7.25 | 20 with sonication |
Preparing Stock Solutions
The following data is based on the product molecular weight 362.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.8 mL | 69 mL | 137.99 mL |
| 1 mM | 2.76 mL | 13.8 mL | 27.6 mL |
| 2 mM | 1.38 mL | 6.9 mL | 13.8 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.76 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Colquhoun et al (2004) Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J.Pharmacol.Exp.Ther. 310 505 PMID: 15051797
Eibl et al (2012) Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor. Neurochem.Int. 61 1266 PMID: 23103525
Longo et al (2008) Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol.Disord.Drug Targets 7 63 PMID: 18289033
If you know of a relevant reference for PD 90780, please let us know.
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Keywords: PD 90780, PD 90780 supplier, PD90780, nonpeptide, inhibitors, inhibits, of, NGF, binding, p75, receptor, TrkA, neuroprotective, nerve, growth, factors, Trk, Receptors, 5101, Tocris Bioscience
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