PD 90780

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Cat.No. 5101 - PD 90780 | C19H14N4O4 | CAS No. 77422-99-2
Description: Inhibits NGF binding to p75NTR
Chemical Name: 7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

A nonpeptide inhibitor of NGF binding to p75NTR (IC50 ~ 1 μM in CHO cells); binds NGF, not p75NTR. Affinity maybe altered by the presence of TrkA receptors. Neuroprotective.

Technical Data

M. Wt 362.34
Formula C19H14N4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 77422-99-2
PubChem ID 9885305
InChI Key IAZAGXDMMVWYKF-UHFFFAOYSA-N
Smiles O=C(C4=CC=CC=C4)NC1=CC=C3C(C(N2C(N3C)=CC(C(O)=O)=N2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 7.25 20 with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 362.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.8 mL 69 mL 137.99 mL
1 mM 2.76 mL 13.8 mL 27.6 mL
2 mM 1.38 mL 6.9 mL 13.8 mL
10 mM 0.28 mL 1.38 mL 2.76 mL

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References

References are publications that support the biological activity of the product.

Colquhoun et al (2004) Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J.Pharmacol.Exp.Ther. 310 505 PMID: 15051797

Eibl et al (2012) Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor. Neurochem.Int. 61 1266 PMID: 23103525

Longo et al (2008) Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol.Disord.Drug Targets 7 63 PMID: 18289033


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Keywords: PD 90780, PD 90780 supplier, PD90780, nonpeptide, inhibitors, inhibits, of, NGF, binding, p75, receptor, TrkA, neuroprotective, nerve, growth, factors, Trk, Receptors, 5101, Tocris Bioscience

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