PD 404182

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Cat.No. 5124 - PD 404182 | C11H11N3S | CAS No. 72596-74-8
Description: High affinity inhibitor of KDO 8-P synthase; also DDAH1 inhibitor
Chemical Name: 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

High affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria.

Technical Data

M. Wt 217.29
Formula C11H11N3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 72596-74-8
PubChem ID 6603967
Smiles N=C2SC1=CC=CC=C1C3=NCCCN23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 21.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 217.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.6 mL 23.01 mL 46.02 mL
5 mM 0.92 mL 4.6 mL 9.2 mL
10 mM 0.46 mL 2.3 mL 4.6 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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References are publications that support the biological activity of the product.

Birck et al (2000) Identification of a slow tight-binding inhibitor of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase. J.Am.Chem.Soc. 122 9334

Ghebremariam et al (2013) A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J.Pharmacol.Exp.Ther. 348 69 PMID: 24135074

Chamoun-Emanuelli et al (2014) Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob.Agents Chemother. 58 687 PMID: 24217696

If you know of a relevant reference for PD 404182, please let us know.

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Citations for PD 404182

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