PD 404182

Discontinued Product

PD 404182 (Cat. No. 5124) has been withdrawn from sale for commercial reasons.
Cat.No. 5124 - PD 404182 | C11H11N3S | CAS No. 72596-74-8
Description: High affinity inhibitor of KDO 8-P synthase; also DDAH1 inhibitor
Chemical Name: 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

High affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria.

Technical Data

M. Wt 217.29
Formula C11H11N3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 72596-74-8
PubChem ID 6603967
InChI Key JNENSSREQFBZGT-UHFFFAOYSA-N
Smiles N=C2SC1=CC=CC=C1C3=NCCCN23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Birck et al (2000) Identification of a slow tight-binding inhibitor of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase. J.Am.Chem.Soc. 122 9334

Ghebremariam et al (2013) A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J.Pharmacol.Exp.Ther. 348 69 PMID: 24135074

Chamoun-Emanuelli et al (2014) Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob.Agents Chemother. 58 687 PMID: 24217696

View Related Products by Product Action

View all Other Synthase/Synthetase Inhibitors

Keywords: PD 404182, PD 404182 supplier, PD404182, antibiotics, KDO8-P, antivirals, antiangiogenics, angiogenesis, gram, negative, DDAH1, 3-deoxy-D-manno-octulosonic, acid, 8-phosphate, synthase, dimethylarginine, dimethylaminohydrolase, 1, inhibits, inhibitors, Other, Synthases/Synthetases, Hydrolases, 5124, Tocris Bioscience

Citations for PD 404182

Citations are publications that use Tocris products.

Currently there are no citations for PD 404182.

Reviews for PD 404182

There are currently no reviews for this product. Be the first to review PD 404182 and earn rewards!

Have you used PD 404182?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis