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Biological Activity for PD 404182
High affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria.
Technical Data for PD 404182
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for PD 404182
References are publications that support the biological activity of the product.
Birck et al (2000) Identification of a slow tight-binding inhibitor of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase. J.Am.Chem.Soc. 122 9334
Ghebremariam et al (2013) A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J.Pharmacol.Exp.Ther. 348 69 PMID: 24135074
Chamoun-Emanuelli et al (2014) Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob.Agents Chemother. 58 687 PMID: 24217696
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Keywords: PD 404182, PD 404182 supplier, PD404182, antibiotics, KDO8-P, antivirals, antiangiogenics, angiogenesis, gram, negative, DDAH1, 3-deoxy-D-manno-octulosonic, acid, 8-phosphate, synthase, dimethylarginine, dimethylaminohydrolase, 1, inhibits, inhibitors, Other, Synthases/Synthetases, Hydrolases, 5124, Tocris Bioscience
Citations for PD 404182
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Currently there are no citations for PD 404182.
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Literature in this Area
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