PD 404182

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Cat.No. 5124 - PD 404182 | C11H11N3S | CAS No. 72596-74-8
Description: High affinity inhibitor of KDO 8-P synthase; also DDAH1 inhibitor
Chemical Name: 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria.

Technical Data

M. Wt 217.29
Formula C11H11N3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 72596-74-8
PubChem ID 6603967
InChI Key JNENSSREQFBZGT-UHFFFAOYSA-N
Smiles N=C2SC1=CC=CC=C1C3=NCCCN23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 21.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 217.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.6 mL 23.01 mL 46.02 mL
5 mM 0.92 mL 4.6 mL 9.2 mL
10 mM 0.46 mL 2.3 mL 4.6 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Birck et al (2000) Identification of a slow tight-binding inhibitor of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase. J.Am.Chem.Soc. 122 9334 PMID:

Ghebremariam et al (2013) A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J.Pharmacol.Exp.Ther. 348 69 PMID: 24135074

Chamoun-Emanuelli et al (2014) Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob.Agents Chemother. 58 687 PMID: 24217696


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Keywords: PD 404182, supplier, PD404182, antibiotics, KDO8-P, antivirals, antiangiogenics, angiogenesis, gram, negative, DDAH1, 3-deoxy-D-manno-octulosonic, acid, 8-phosphate, synthase, dimethylarginine, dimethylaminohydrolase, 1, inhibits, inhibitors, Other, Synthases/Synthetases, Other, Hydrolases, Other, Synthases/Synthetases, Tocris Bioscience

Citations for PD 404182

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