Discontinued ProductUnfortunately PD 168368 (Cat. No. 2603) has been withdrawn from sale for commercial reasons.
Potent neuromedin B receptor antagonist (NMB-R, BB1) (IC50 = 40 nM) that displays ~ 40-fold selectivity over the gastrin-releasing peptide receptor (GRP-R, BB2) and > 300-fold selectivity over BRS-R (bb3). Antagonizes neuromedin B-stimulated calcium release and inhibits proliferation of rat glioma cells (IC50 = 2 μM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 554.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.8 mL||9.01 mL||18.03 mL|
|5 mM||0.36 mL||1.8 mL||3.61 mL|
|10 mM||0.18 mL||0.9 mL||1.8 mL|
|50 mM||0.04 mL||0.18 mL||0.36 mL|
References are publications that support the products' biological activity.
Ryan et al (1999) Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368 J.Pharmacol.Exp.Ther. 290 1202 PMID: 10454496
Moody et al (2000) Nonpeptide neuromedin B receptor antagonists inhibit the proliferation of C6 cells. Eur.J.Pharmacol. 409 133 PMID: 11104826
Moody et al (2003) Nonpeptide gastrin releasing peptide receptor antagonists inhibit the proliferation of lung cancer cells. Eur.J.Pharmacol. 474 21 PMID: 12909192
Schepetkin et al (2011) Gastrin-releasing peptide/neuromedin B receptor antagonists pD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. Mol.Pharmacol. 79 77 PMID: 20943772
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Keywords: PD 168368, supplier, Selective, neuromedin, B, receptor, antagonists, NMB-R, BB1, NMB-Preferring, Bombesin, PD168368, Bombesin, Receptors, Bombesin, Receptors, Tocris Bioscience
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