PD 160170

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Cat.No. 2200 - PD 160170 | C18H17N3O4S | CAS No. 181468-88-2
Description: Selective non-peptide NPY Y1 receptor antagonist
Chemical Name: 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity

Potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM); selective over Y2 and Y5 receptors (Ki > 10 μM). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC50 = 8.2 nM).

Compound Libraries

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Technical Data

M. Wt 371.41
Formula C18H17N3O4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 181468-88-2
PubChem ID 9820766
Smiles CC(C)C1=CC=CC=C1S(=O)(=O)C1=CC(N)=C2N=CC=CC2=C1[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 371.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References are publications that support the biological activity of the product.

Wright et al (1996) 8-Amino-6-(arylsulphonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonists. Bioorg.Med.Chem.Lett. 6 1809

Wielgosz-Collin et al (2002) 8-Amino-5-nitro-6-phenoxyquinolines:potential non-peptidic neuropeptide Y receptor ligands. J.Enz.Inhib.Med.Chem. 17 449

If you know of a relevant reference for PD 160170, please let us know.

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Keywords: PD 160170, PD 160170 supplier, Selective, non-peptide, NPY, Y1, antagonists, Neuropeptide, Y, Receptors, PD160170, neuropeptides, 2200, Tocris Bioscience

2 Citations for PD 160170

Citations are publications that use Tocris products. Selected citations for PD 160170 include:

Zambrano et al (2015) Density of α4β2* nAChR on the surface of neurons is modulated by chronic antagonist exposure. Pharmacol Res Perspect 3 e00111 PMID: 25729578

Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Physiol Rep 488 172 PMID: 22801496

Do you know of a great paper that uses PD 160170 from Tocris? Please let us know.

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