PD 160170

Pricing Availability Delivery Time Qty
Cat.No. 2200 - PD 160170 | C18H17N3O4S | CAS No. 181468-88-2
Description: Selective non-peptide NPY Y1 receptor antagonist
Chemical Name: 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM); selective over Y2 and Y5 receptors (Ki > 10 μM). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC50 = 8.2 nM).

Compound Libraries

PD 160170 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 371.41
Formula C18H17N3O4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 181468-88-2
PubChem ID 9820766
InChI Key YUVNGBZROXQYQH-UHFFFAOYSA-N
Smiles CC(C)C1=CC=CC=C1S(=O)(=O)C1=CC(N)=C2N=CC=CC2=C1[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 371.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wright et al (1996) 8-Amino-6-(arylsulphonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonists. Bioorg.Med.Chem.Lett. 6 1809 PMID:

Wielgosz-Collin et al (2002) 8-Amino-5-nitro-6-phenoxyquinolines:potential non-peptidic neuropeptide Y receptor ligands. J.Enz.Inhib.Med.Chem. 17 449 PMID:


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Keywords: PD 160170, supplier, Selective, non-peptide, NPY, Y1, antagonists, Neuropeptide, Y, Receptors, PD160170, neuropeptides, NPY, Receptors, NPY, Receptors, Tocris Bioscience

2 Citations for PD 160170

Citations are publications that use Tocris products. Selected citations for PD 160170 include:

Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Physiol Rep 488 172 PMID: 22801496

Zambrano et al (2015) Density of α4β2* nAChR on the surface of neurons is modulated by chronic antagonist exposure. Pharmacol Res Perspect 3 e00111 PMID: 25729578


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