PCA 4248

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Cat.No. 0571 - PCA 4248 | C19H23NO4S | CAS No. 123875-01-4
Description: PAF receptor antagonist
Chemical Name: 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid methyl 2-(phenylthio)ethyl ester
Purity: ≥95%
Datasheet
Citations (4)
Literature

Biological Activity

A specific PAF antagonist, more potent than the ginkolide BN-52021. Inhibits rabbit platelet aggregation with an IC50 value of 1.05 μM and has no significant activity on Ca2+ channels. Active in vivo, antagonizing PAF-induced systemic hypotension and protein-plasma extravasation in rats.

Compound Libraries

PCA 4248 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 361.46
Formula C19H23NO4S
Storage Desiccate at -20°C
Purity ≥95%
CAS Number 123875-01-4
PubChem ID 4698
InChI Key DHCNAWNKZMNTIS-UHFFFAOYSA-N
Smiles COC(=O)C1=C(C)NC(C)=C(C1C)C(=O)OCCSC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.14 100
ethanol 36.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 361.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.83 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Fernandez-Gallardo et al (1990) Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonist: in vivo studies. J.Pharmacol.Exp.Ther. 255 34 PMID: 2170626

Sunkel et al (1990) 4-Alkyl-1,4-dihydropyridine derivatives as specific PAF-acether antagonists. J.Med.Chem. 33 3205 PMID: 2175357

Sunkel et al (1990) 1,4-Dihydropyridines, a new class of platelet activating factor receptor antagonists: in vitro pharmacological studies. J.Pharmacol.Exp.Ther. 255 28 PMID: 2170624


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Keywords: PCA 4248, supplier, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, PCA4248, Platelet-activating, Factor, (PAF), Receptors, Platelet-activating, Factor, (PAF), Receptors, Tocris Bioscience

4 Citations for PCA 4248

Citations are publications that use Tocris products. Selected citations for PCA 4248 include:

Hergott et al (2015) Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection. Mediators Inflamm 125 3878 PMID: 26426079

Bachi et al (2012) Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. J Pharmacol Exp Ther 2012 610371 PMID: 22577252

Garcia et al (2010) Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice. PLoS Pathog 6 e1001171 PMID: 21079759

Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247 PMID: 15249429


Do you know of a great paper that uses PCA 4248 from Tocris? If so please let us know.

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Literature in this Area

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Pathways for PCA 4248

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