JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor (IC50 values are 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Increases levels of methylated H3K4 in JARIDB1-transfected HeLa cells and MCF7 cells. Inhibits proliferation of breast cancer cell lines expressing high levels of JARIDB1.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 241.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.14 mL||20.72 mL||41.44 mL|
|5 mM||0.83 mL||4.14 mL||8.29 mL|
|10 mM||0.41 mL||2.07 mL||4.14 mL|
|50 mM||0.08 mL||0.41 mL||0.83 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Sayegh et al (2013) Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J.Biol.Chem. 288 9408 PMID: 23408432
If you know of a relevant reference for PBIT, please let us know.
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Keywords: PBIT, supplier, Jumonji, AT-Rich, Interactive, Domain, 1, JARID1B, histone, lysine, demethylase, inhibitors, inhibits, breast, cancer, Histone, Demethylases, Histone, Demethylases, Tocris Bioscience
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Literature in this Area
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Epigenetics Research Bulletin
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