Discontinued Product

PBIT (Cat. No. 5930) has been withdrawn from sale for commercial reasons.
Description: JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor
Chemical Name: 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for PBIT

PBIT is a JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor (IC50 values are 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Increases levels of methylated H3K4 in JARIDB1-transfected HeLa cells and MCF7 cells. Inhibits proliferation of breast cancer cell lines expressing high levels of JARIDB1.

Technical Data for PBIT

M. Wt 241.31
Formula C14H11NOS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 2514-30-9
PubChem ID 935415
Smiles CC1=CC=C(N2SC3=C(C2=O)C=CC=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PBIT

References are publications that support the biological activity of the product.

Sayegh et al (2013) Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J.Biol.Chem. 288 9408 PMID: 23408432

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Keywords: PBIT, PBIT supplier, Jumonji, AT-Rich, Interactive, Domain, 1, JARID1B, histone, lysine, demethylase, inhibitors, inhibits, breast, cancer, Histone, Demethylases, 5930, Tocris Bioscience

Citations for PBIT

Citations are publications that use Tocris products.

Currently there are no citations for PBIT.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.