PB 28 dihydrochloride
High affinity σ2 receptor agonist (Ki values are 0.8 and 15.2 nM for σ2 and σ1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50 values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||8.87||20mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 443.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.25 mL||11.27 mL||22.55 mL|
|5 mM||0.45 mL||2.25 mL||4.51 mL|
|10 mM||0.23 mL||1.13 mL||2.25 mL|
|50 mM||0.05 mL||0.23 mL||0.45 mL|
References are publications that support the products' biological activity.
Berardi et al (1996) New σ and 5-HT1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives. J.Med.Chem. 39 176 PMID: 8568804
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Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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