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Toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.
(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl]-Cys
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in 50% Ethanol / water|
References are publications that support the biological activity of the product.
St Paul et al (2012) Toll-like receptor ligands induce the expression of IF.-gamma and interleukin-17 in chicken CD4+ T cells. BMC Res.Notes 1 616 PMID: 23116495
Offermanns et al (1992) Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochem.J. 282 551 PMID: 1312332
Caproni et al (2012) MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action. J.Immunol. 188 3088 PMID: 22351935
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Keywords: Pam3CSK4, Pam3CSK4 supplier, toll, like, receptors, TLRs, agonists, ligands, induces, cytokines, production, IFNg, TNFa, TNFalpha, IL-6, interleukin, Toll-like, Receptors, 4633, Tocris Bioscience
Citations for Pam3CSK4
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Reviews for Pam3CSK4
Average Rating: 5 (Based on 2 Reviews.)
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Raw-Blue Cell lines were treated with 125 ng/ml of PAM3CSK4 and the level of SEAP was measured. SEAP level correlates with NFkB activation
I use this product to activate TLR2
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