Pam3CSK4

Pricing Availability Delivery Time Qty
Cat.No. 4633 - Pam3CSK4 | Pam3-Cys-Ser-Lys-Lys-Lys-Lys | CAS No. 112208-00-1
Description: TLR1/2 agonist; induces cytokine production
Datasheet
Citations
Reviews (1)
Literature
Pathways

Biological Activity

Toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.

Technical Data

M. Wt 1510.24
Formula C81H156N10O13S
Sequence CSKKKK

(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl]-Cys

Storage Store at -20°C
CAS Number 112208-00-1
PubChem ID 130704
InChI Key OEDPHAKKZGDBEV-GFPBKZJXSA-N
Smiles [H]N([C@@H](CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)CCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in 50% Ethanol / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1510.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.66 mL 3.31 mL 6.62 mL
5 mM 0.13 mL 0.66 mL 1.32 mL
10 mM 0.07 mL 0.33 mL 0.66 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

St Paul et al (2012) Toll-like receptor ligands induce the expression of interferon-gamma and interleukin-17 in chicken CD4+ T cells. BMC Res.Notes 1 616 PMID: 23116495

Offermanns et al (1992) Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochem.J. 282 551 PMID: 1312332

Caproni et al (2012) MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action. J.Immunol. 188 3088 PMID: 22351935


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Keywords: Pam3CSK4, Pam3CSK4 supplier, toll, like, receptors, TLRs, agonists, ligands, induces, cytokines, production, IFNg, TNFa, TNFalpha, IL-6, interleukin, Toll-like, Receptors, 4633, Tocris Bioscience

Citations for Pam3CSK4

Citations are publications that use Tocris products.

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Reviews for Pam3CSK4

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Good product!
By Anonymous on 04/24/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: THP1

I use this product to activate TLR2


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Pathways for Pam3CSK4

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.