Pam3CSK4

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Cat.No. 4633 - Pam3CSK4 | Pam3-Cys-Ser-Lys-Lys-Lys-Lys | CAS No. 112208-00-1
Description: TLR1/2 agonist; induces cytokine production
Datasheet
Citations
Literature
Pathways

Biological Activity

Toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.

Technical Data

M. Wt 1510.24
Formula C81H156N10O13S
Sequence CSKKKK

(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl]-Cys

Storage Store at -20°C
CAS Number 112208-00-1
PubChem ID 130704
InChI Key OEDPHAKKZGDBEV-GFPBKZJXSA-N
Smiles [H]N([C@@H](CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)CCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 50% Ethanol / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1510.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.66 mL 3.31 mL 6.62 mL
5 mM 0.13 mL 0.66 mL 1.32 mL
10 mM 0.07 mL 0.33 mL 0.66 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

St Paul et al (2012) Toll-like receptor ligands induce the expression of interferon-gamma and interleukin-17 in chicken CD4+ T cells. BMC Res.Notes 1 616 PMID: 23116495

Offermanns et al (1992) Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochem.J. 282 551 PMID: 1312332

Caproni et al (2012) MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action. J.Immunol. 188 3088 PMID: 22351935


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Keywords: toll like receptors TLRs agonists ligands induces cytokines production IFNg TNFa TNFalpha IL-6 interleukin Toll-like Receptors

Citations for Pam3CSK4

Citations are publications that use Tocris products.

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Literature in this Area

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Pathways for Pam3CSK4

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.

Protocols

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