Palmitoylisopropylamide

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Cat.No. 1815 - Palmitoylisopropylamide | C19H39NO | CAS No. 189939-61-5
Description: Inhibitor of FAAH
Alternative Names: PIA
Chemical Name: N-(1-Methylethyl)-hexadecanamide
Datasheet
Citations
Literature

Biological Activity

Inhibitor of fatty acid amide hydrolase (FAAH); pIC50 = 4.89 for inhibition of [3H]-anandamide metabolism. Displays little binding to CB1 and CB2 receptors (IC50 > 100 μM) and very weakly blocks anandamide uptake (IC50 ~ 100 μM). Inhibits proliferation of C6 glioma cells.

Technical Data

M. Wt 297.52
Formula C19H39NO
Storage Store at RT
CAS Number 189939-61-5
PubChem ID 5063962
InChI Key TZYVUGCYYQOTQR-UHFFFAOYSA-N
Smiles CCCCCCCCCCCCCCCC(NC(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.98 10
ethanol 29.75 100

Preparing Stock Solutions

The following data is based on the product molecular weight 297.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.81 mL 33.61 mL
5 mM 0.67 mL 3.36 mL 6.72 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Jonsson et al (2001) Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. Br.J.Pharmacol. 133 1263 PMID: 11498512

Jonsson et al (2003) AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch.Toxicol. 77 201 PMID: 12698235


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Keywords: inhibitors inhibits FAAH cannabinoids Receptors Anandamide Amidase Fatty Acid Amide Hydrolases PIA Other Cannabinoids

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Literature in this Area

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Pathways for Palmitoylisopropylamide

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