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Palmitoylisopropylamide is an inhibitor of fatty acid amide hydrolase (FAAH); pIC50 = 4.89 for inhibition of [3H]-anandamide metabolism. Displays little binding to CB1 and CB2 receptors (IC50 > 100 μM) and very weakly blocks anandamide uptake (IC50 ~ 100 μM). Inhibits proliferation of C6 glioma cells.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Jonsson et al (2001) Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. Br.J.Pharmacol. 133 1263 PMID: 11498512
Jonsson et al (2003) AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch.Toxicol. 77 201 PMID: 12698235
Keywords: Palmitoylisopropylamide, Palmitoylisopropylamide supplier, inhibitors, inhibits, FAAH, cannabinoids, Receptors, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, PIA, Other, Cannabinoids, Hydrolase, (FAAH), 1815, Tocris Bioscience
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