Discontinued Product

Palmitoylisopropylamide (Cat. No. 1815) has been withdrawn from sale for commercial reasons.
Description: Inhibitor of FAAH
Alternative Names: PIA
Chemical Name: N-(1-Methylethyl)-hexadecanamide
Literature (1)

Biological Activity for Palmitoylisopropylamide

Palmitoylisopropylamide is an inhibitor of fatty acid amide hydrolase (FAAH); pIC50 = 4.89 for inhibition of [3H]-anandamide metabolism. Displays little binding to CB1 and CB2 receptors (IC50 > 100 μM) and very weakly blocks anandamide uptake (IC50 ~ 100 μM). Inhibits proliferation of C6 glioma cells.

Technical Data for Palmitoylisopropylamide

M. Wt 297.52
Formula C19H39NO
Storage Store at RT
CAS Number 189939-61-5
PubChem ID 5063962

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Palmitoylisopropylamide

References for Palmitoylisopropylamide

References are publications that support the biological activity of the product.

Jonsson et al (2001) Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. Br.J.Pharmacol. 133 1263 PMID: 11498512

Jonsson et al (2003) AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch.Toxicol. 77 201 PMID: 12698235

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Keywords: Palmitoylisopropylamide, Palmitoylisopropylamide supplier, inhibitors, inhibits, FAAH, cannabinoids, Receptors, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, PIA, Other, Cannabinoids, Hydrolase, (FAAH), 1815, Tocris Bioscience

Citations for Palmitoylisopropylamide

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Currently there are no citations for Palmitoylisopropylamide.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.