PALDA

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Cat.No. 2203 - PALDA | C24H41NO3 | CAS No. 136181-87-8
Description: Endogenous lipid; potentiates effects of endovanilloids at TRPV1 receptors
Alternative Names: N-Palmitoyldopamine
Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]hexadecanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA; lowers EC50 from ~ 90 to ~ 30 nM.

Technical Data

M. Wt 391.59
Formula C24H41NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 136181-87-8
PubChem ID 16759163
InChI Key TWJJFOWLTIEYFO-UHFFFAOYSA-N
Smiles CCCCCCCCCCCCCCCC(=O)NCCC1=CC(O)=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 1.95 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 391.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Chu et al (2003) N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633 PMID: 12569099

De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251 PMID: 15289293


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View Related Products by Target

Keywords: Endogenous lipid potentiates effects endovanilloids TRPV1 receptors Vanillioid Receptors VR1 TRPV TRP Channels Transient Receptor Potential N-Palmitoyldopamine TRPV

Citations for PALDA

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Literature in this Area

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Pain Research Product Guide

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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for PALDA

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