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Cat.No. 2203 - PALDA | C24H41NO3 | CAS No. 136181-87-8
Description: Endogenous lipid; potentiates effects of endovanilloids at TRPV1 receptors
Alternative Names: N-Palmitoyldopamine
Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]hexadecanamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity

Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA; lowers EC50 from ~ 90 to ~ 30 nM.

Technical Data

M. Wt 391.59
Formula C24H41NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 136181-87-8
PubChem ID 16759163

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 1.95 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 391.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 51.07 mL 255.37 mL 510.74 mL
0.25 mM 10.21 mL 51.07 mL 102.15 mL
0.5 mM 5.11 mL 25.54 mL 51.07 mL
2.5 mM 1.02 mL 5.11 mL 10.21 mL

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References are publications that support the biological activity of the product.

Chu et al (2003) N-OleoylDA, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633 PMID: 12569099

De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acylDAs on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251 PMID: 15289293

If you know of a relevant reference for PALDA, please let us know.

View Related Products by Target

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Citations for PALDA

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Literature in this Area

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