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Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA; lowers EC50 from ~ 90 to ~ 30 nM.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||1.95||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 391.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||51.07 mL||255.37 mL||510.74 mL|
|0.25 mM||10.21 mL||51.07 mL||102.15 mL|
|0.5 mM||5.11 mL||25.54 mL||51.07 mL|
|2.5 mM||1.02 mL||5.11 mL||10.21 mL|
References are publications that support the biological activity of the product.
Chu et al (2003) N-OleoylDA, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633 PMID: 12569099
De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acylDAs on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251 PMID: 15289293
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Keywords: PALDA, PALDA supplier, Endogenous, lipid, potentiates, effects, endovanilloids, TRPV1, receptors, Vanillioid, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, N-Palmitoyldopamine, 2203, Tocris Bioscience
Citations for PALDA
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.