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Cat.No. 1460 - PACOCF3 | C17H31F3O | CAS No. 141022-99-3
Description: Phospholipase A2 inhibitor
Alternative Names: Palmityl trifluoromethyl ketone
Chemical Name: 1,1,1-Trifluoro-2-heptadecanone
Purity: ≥99% (HPLC)
Citations (3)
Literature (3)

Biological Activity for PACOCF3

PACOCF3 is a phospholipase A2 inhibitor. Can also alter Ca2+ signaling in renal tubular cells.

Technical Data for PACOCF3

M. Wt 308.43
Formula C17H31F3O
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 141022-99-3
PubChem ID 4670

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PACOCF3

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 50

Preparing Stock Solutions for PACOCF3

The following data is based on the product molecular weight 308.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.48 mL 32.42 mL 64.84 mL
2.5 mM 1.3 mL 6.48 mL 12.97 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
25 mM 0.13 mL 0.65 mL 1.3 mL

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References for PACOCF3

References are publications that support the biological activity of the product.

Ackermann et al (1995) Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J.Biol.Chem. 270 445 PMID: 7814408

Jan et al (2000) Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch.Toxicol. 74 447 PMID: 11097381

Lio et al (1996) Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim.Biophys.Acta 1302 55 PMID: 8695655

If you know of a relevant reference for PACOCF3, please let us know.

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Keywords: PACOCF3, PACOCF3 supplier, Phospholipases, A2, inhibitors, inhibits, PLA2, Esterases, Palmityl, trifluoromethyl, ketone, 1460, Tocris Bioscience

3 Citations for PACOCF3

Citations are publications that use Tocris products. Selected citations for PACOCF3 include:

Singaravelu et al (2006) Regulation of store-operated calcium entry by calcium-independent phospholipase A2 in rat cerebellar astrocytes. J Neurosci 26 9579 PMID: 16971542

Qiu et al (2014) GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex. J Neurosci 34 13505 PMID: 25274827

Potapova et al (2013) Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. J Neurosci 8 e73929 PMID: 24069252

Do you know of a great paper that uses PACOCF3 from Tocris? Please let us know.

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Literature in this Area

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