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Biological Activity for PACOCF3
PACOCF3 is a phospholipase A2 inhibitor. Can also alter Ca2+ signaling in renal tubular cells.
Technical Data for PACOCF3
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PACOCF3
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PACOCF3
The following data is based on the product molecular weight 308.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.48 mL||32.42 mL||64.84 mL|
|2.5 mM||1.3 mL||6.48 mL||12.97 mL|
|5 mM||0.65 mL||3.24 mL||6.48 mL|
|25 mM||0.13 mL||0.65 mL||1.3 mL|
References for PACOCF3
References are publications that support the biological activity of the product.
Ackermann et al (1995) Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J.Biol.Chem. 270 445 PMID: 7814408
Jan et al (2000) Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch.Toxicol. 74 447 PMID: 11097381
Lio et al (1996) Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim.Biophys.Acta 1302 55 PMID: 8695655
If you know of a relevant reference for PACOCF3, please let us know.
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Keywords: PACOCF3, PACOCF3 supplier, Phospholipases, A2, inhibitors, inhibits, PLA2, Esterases, Palmityl, trifluoromethyl, ketone, 1460, Tocris Bioscience
3 Citations for PACOCF3
Citations are publications that use Tocris products. Selected citations for PACOCF3 include:
Singaravelu et al (2006) Regulation of store-operated calcium entry by calcium-independent phospholipase A2 in rat cerebellar astrocytes. J Neurosci 26 9579 PMID: 16971542
Qiu et al (2014) GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex. J Neurosci 34 13505 PMID: 25274827
Potapova et al (2013) Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. J Neurosci 8 e73929 PMID: 24069252
Do you know of a great paper that uses PACOCF3 from Tocris? Please let us know.
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Literature in this Area
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