Phospholipase A2 inhibitor. Can also alter Ca2+ signaling in renal tubular cells.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 25 mM in DMSO and to 50 mM in ethanol|
Preparing Stock Solutions
The following data is based on the product molecular weight 308.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.24 mL||16.21 mL||32.42 mL|
|5 mM||0.65 mL||3.24 mL||6.48 mL|
|10 mM||0.32 mL||1.62 mL||3.24 mL|
|50 mM||0.06 mL||0.32 mL||0.65 mL|
References are publications that support the products' biological activity.
Ackermann et al (1995) Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J.Biol.Chem. 270 445 PMID: 7814408
Jan et al (2000) Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch.Toxicol. 74 447 PMID: 11097381
Lio et al (1996) Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim.Biophys.Acta 1302 55 PMID: 8695655
If you know of a relevant reference for PACOCF3, please let us know.
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Keywords: PACOCF3, supplier, Phospholipases, A2, inhibitors, inhibits, PLA2, Esterases, Palmityl, trifluoromethyl, ketone, Phospholipases, Phospholipases, Tocris Bioscience
2 Citations for PACOCF3
Citations are publications that use Tocris products. Selected citations for PACOCF3 include:
Qiu et al (2014) GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex. J Neurosci 34 13505 PMID: 25274827
Potapova et al (2013) Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. J Neurosci 8 e73929 PMID: 24069252
Do you know of a great paper that uses PACOCF3 from Tocris? If so please let us know.
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