PACOCF3

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Cat.No. 1460 - PACOCF3 | C17H31F3O | CAS No. 141022-99-3
Description: Phospholipase A2 inhibitor
Alternative Names: Palmityl trifluoromethyl ketone
Chemical Name: 1,1,1-Trifluoro-2-heptadecanone
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Phospholipase A2 inhibitor. Can also alter Ca2+ signaling in renal tubular cells.

Technical Data

M. Wt 308.43
Formula C17H31F3O
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 141022-99-3
PubChem ID 4670
InChI Key MAHYXYTYTLCTQD-UHFFFAOYSA-N
Smiles FC(F)(F)C(CCCCCCCCCCCCCCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 25 mM in DMSO and to 50 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 308.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.42 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ackermann et al (1995) Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J.Biol.Chem. 270 445 PMID: 7814408

Jan et al (2000) Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch.Toxicol. 74 447 PMID: 11097381

Lio et al (1996) Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim.Biophys.Acta 1302 55 PMID: 8695655


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Keywords: PACOCF3, supplier, Phospholipases, A2, inhibitors, inhibits, PLA2, Esterases, Palmityl, trifluoromethyl, ketone, Phospholipases, Phospholipases, Tocris Bioscience

2 Citations for PACOCF3

Citations are publications that use Tocris products. Selected citations for PACOCF3 include:

Potapova et al (2013) Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. J Neurosci 8 e73929 PMID: 24069252

Qiu et al (2014) GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex. J Neurosci 34 13505 PMID: 25274827


Do you know of a great paper that uses PACOCF3 from Tocris? If so please let us know.

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