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Description: Protein disulfide isomerase (PDI) inhibitor
Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide
Purity: ≥98% (HPLC)
Biological Activity for P1
P1 is a protein disulfide isomerase (PDI) inhibitor (IC50 = 1.7 μM). Inhibits proliferation of numerous cancer cell lines. Cell permeable.
Technical Data for P1
| M. Wt | 583.7 |
| Formula | C30H37N3O7S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1461648-55-4 |
| PubChem ID | 91826082 |
| InChI Key | RNMDSOKRNOMQFX-UIOOFZCWSA-N |
| Smiles | O=[C@@](NCCCC#C)[C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CC2=CC=CC=C2)=O)CC1=CC=C(OS(C=C)(=O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for P1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.37 | 100 |
Preparing Stock Solutions for P1
The following data is based on the product molecular weight 583.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.71 mL | 8.57 mL | 17.13 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.43 mL |
| 10 mM | 0.17 mL | 0.86 mL | 1.71 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
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Product Datasheets for P1
References for P1
References are publications that support the biological activity of the product.
Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase ACS Chem.Biol. 8 2577 PMID: 24070012
Xu et al (2013) Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PLoS One 8 e76657 PMID: 24098548
If you know of a relevant reference for P1, please let us know.
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Keywords: P1, P1 supplier, Protein, disulfide, Isomerase, PDI, inhibitors, inhibits, Disulfide, 5127, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
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- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
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