Pricing Availability   Qty
Description: Protein disulfide isomerase (PDI) inhibitor
Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for P1

P1 is a protein disulfide isomerase (PDI) inhibitor (IC50 = 1.7 μM). Inhibits proliferation of numerous cancer cell lines. Cell permeable.

Technical Data for P1

M. Wt 583.7
Formula C30H37N3O7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1461648-55-4
PubChem ID 91826082
Smiles O=[C@@](NCCCC#C)[C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CC2=CC=CC=C2)=O)CC1=CC=C(OS(C=C)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for P1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 58.37 100

Preparing Stock Solutions for P1

The following data is based on the product molecular weight 583.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.71 mL 8.57 mL 17.13 mL
5 mM 0.34 mL 1.71 mL 3.43 mL
10 mM 0.17 mL 0.86 mL 1.71 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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References for P1

References are publications that support the biological activity of the product.

Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase ACS Chem.Biol. 8 2577 PMID: 24070012

Xu et al (2013) Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PLoS One 8 e76657 PMID: 24098548

If you know of a relevant reference for P1, please let us know.

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Keywords: P1, P1 supplier, Protein, disulfide, Isomerase, PDI, inhibitors, inhibits, Disulfide, 5127, Tocris Bioscience

1 Citation for P1

Citations are publications that use Tocris products. Selected citations for P1 include:

Chia-Yi et al (2022) Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein-mediated viral translation. JCI Insight 7 PMID: 36125898

Do you know of a great paper that uses P1 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Gut Hormones Poster

Gut Hormones Poster

The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.