P1

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Cat.No. 5127 - P1 | C30H37N3O7S | CAS No. 1461648-55-4
Description: Protein disulfide isomerase (PDI) inhibitor
Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Protein disulfide isomerase (PDI) inhibitor (IC50 = 1.7 μM). Inhibits proliferation of numerous cancer cell lines. Cell permeable.

Technical Data

M. Wt 583.7
Formula C30H37N3O7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1461648-55-4
PubChem ID 91826082
InChI Key RNMDSOKRNOMQFX-UIOOFZCWSA-N
Smiles O=[C@@](NCCCC#C)[C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CC2=CC=CC=C2)=O)CC1=CC=C(OS(C=C)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.37 100

Preparing Stock Solutions

The following data is based on the product molecular weight 583.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.71 mL 8.57 mL 17.13 mL
5 mM 0.34 mL 1.71 mL 3.43 mL
10 mM 0.17 mL 0.86 mL 1.71 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase ACS Chem.Biol. 8 2577 PMID: 24070012

Xu et al (2013) Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PLoS One 8 e76657 PMID: 24098548


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Citations for P1

Citations are publications that use Tocris products.

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Literature in this Area

Cancer

Cancer Research Product Guide

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  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
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Cardiovascular

Cardiovascular Research Product Guide

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Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
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Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Gut Hormones

Gut Hormones Poster

The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.

Pathways for P1

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