Discontinued Product

Unfortunately p-DITC-APEC (Cat. No. 2405) has been withdrawn from sale for commercial reasons.
Cat.No. 2405 - p-DITC-APEC | C33H39N11O5S2
Description: Irreversible A2A agonist
Chemical Name: 2-[4-[2-[2-[(4-Isothiocyanatophenyl)thiocarbonylamino]ethylaminocarbonyl]ethyl]phenethylamino]-5'-N-ethylcarboxamidadenosine
Purity: ≥95% (HPLC)

Biological Activity

Irreversible A2A receptor agonist (apparent Ki = 9.9 nM). Displays > 8-fold selectivity for A2 versus A1 receptors (Ki values are 35 and 276 nM for rat A2 and A1 receptors respectively). Produces progressive concentration-independent vasodilation in guinea pig heart Langendorff preparations.

Technical Data

M. Wt 733.86
Formula C33H39N11O5S2
Storage Store at -20°C
Purity ≥95% (HPLC)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 733.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.36 mL 6.81 mL 13.63 mL
5 mM 0.27 mL 1.36 mL 2.73 mL
10 mM 0.14 mL 0.68 mL 1.36 mL
50 mM 0.03 mL 0.14 mL 0.27 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet


References are publications that support the products' biological activity.

Jacobson et al (1992) Chemical modification and irreversible inhibition of striatal A2A adenosine receptors. Mol.Pharmacol. 42 123 PMID: 1635550

Jacobson et al (1989) Agonist derived molecular probes for A2 adenosine receptors. J.Mol.Recog. 2 170 PMID:

Niiya et al (1993) Covalent binding of a selective agonist irreversibly activates guinea pig coronary artery A2 adenosine receptors. Naunyn-Schmied.Arch.Pharmacol. 347 521 PMID:

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Keywords: p-DITC-APEC, supplier, A2A, adenosines, agonist, Adenosine, A2A, Receptors, Adenosine, A2A, Receptors, Tocris Bioscience

Citations for p-DITC-APEC

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Literature in this Area

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