p-DITC-APEC

Name: p- DITC-APEC
Brand: Tocris Bioscience
SKU: 2405

Cat. No. 2405 Submit a Review Datasheet / COA / SDS

Discontinued Product

p-DITC-APEC (Cat. No. 2405) has been withdrawn from sale for commercial reasons.

Description: Irreversible A_2A agonist

Chemical Name: 2-[4-[2-[2-[(4-Isothiocyanatophenyl)thiocarbonylamino]ethylaminocarbonyl]ethyl]phenethylamino]-5'-N-ethylcarboxamidadenosine

Purity: ≥95% (HPLC)

Datasheet

Citations

Reviews

Literature (1)

Biological Activity Technical Data Datasheets References

Biological Activity for p-DITC-APEC

Irreversible A_2A receptor agonist (apparent K_i = 9.9 nM). Displays > 8-fold selectivity for A₂ versus A₁ receptors (K_i values are 35 and 276 nM for rat A₂ and A₁ receptors respectively). Produces progressive concentration-independent vasodilation in guinea pig heart Langendorff preparations.

Technical Data for p-DITC-APEC

M. Wt	733.86
Formula	C₃₃H₃₉N₁₁O₅S₂
Storage	Store at -20°C
Purity	≥95% (HPLC)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for p-DITC-APEC

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

Safety Datasheet

References for p-DITC-APEC

References are publications that support the biological activity of the product.

Jacobson et al (1992) Chemical modification and irreversible inhibition of striatal A_2A adenosine receptors. Mol.Pharmacol. 42 123 PMID: 1635550

Jacobson et al (1989) Agonist derived molecular probes for A₂ adenosine receptors. J.Mol.Recog. 2 170

Niiya et al (1993) Covalent binding of a selective agonist irreversibly activates guinea pig coronary artery A₂ adenosine receptors. Naunyn-Schmied.Arch.Pharmacol. 347 521

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Keywords: p-DITC-APEC, p-DITC-APEC supplier, A2A, adenosines, agonist, Adenosine, Receptors, 2405, Tocris Bioscience

Citations for p-DITC-APEC

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Currently there are no citations for p-DITC-APEC.

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Literature in this Area

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