p-DITC-APEC

Discontinued Product

p-DITC-APEC (Cat. No. 2405) has been withdrawn from sale for commercial reasons.
Cat.No. 2405 - p-DITC-APEC | C33H39N11O5S2
Description: Irreversible A2A agonist
Chemical Name: 2-[4-[2-[2-[(4-Isothiocyanatophenyl)thiocarbonylamino]ethylaminocarbonyl]ethyl]phenethylamino]-5'-N-ethylcarboxamidadenosine
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Irreversible A2A receptor agonist (apparent Ki = 9.9 nM). Displays > 8-fold selectivity for A2 versus A1 receptors (Ki values are 35 and 276 nM for rat A2 and A1 receptors respectively). Produces progressive concentration-independent vasodilation in guinea pig heart Langendorff preparations.

Technical Data

M. Wt 733.86
Formula C33H39N11O5S2
Storage Store at -20°C
Purity ≥95% (HPLC)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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References

References are publications that support the biological activity of the product.

Jacobson et al (1992) Chemical modification and irreversible inhibition of striatal A2A adenosine receptors. Mol.Pharmacol. 42 123 PMID: 1635550

Jacobson et al (1989) Agonist derived molecular probes for A2 adenosine receptors. J.Mol.Recog. 2 170

Niiya et al (1993) Covalent binding of a selective agonist irreversibly activates guinea pig coronary artery A2 adenosine receptors. Naunyn-Schmied.Arch.Pharmacol. 347 521

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Keywords: p-DITC-APEC, p-DITC-APEC supplier, A2A, adenosines, agonist, Adenosine, Receptors, 2405, Tocris Bioscience

Citations for p-DITC-APEC

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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