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Discontinued Product
p-DITC-APEC (Cat. No. 2405) has been withdrawn from sale for commercial reasons.
Description: Irreversible A2A agonist
Chemical Name: 2-[4-[2-[2-[(4-Isothiocyanatophenyl)thiocarbonylamino]ethylaminocarbonyl]ethyl]phenethylamino]-5'-N-ethylcarboxamidadenosine
Purity: ≥95% (HPLC)
Biological Activity for p-DITC-APEC
Irreversible A2A receptor agonist (apparent Ki = 9.9 nM). Displays > 8-fold selectivity for A2 versus A1 receptors (Ki values are 35 and 276 nM for rat A2 and A1 receptors respectively). Produces progressive concentration-independent vasodilation in guinea pig heart Langendorff preparations.
Technical Data for p-DITC-APEC
| M. Wt | 733.86 |
| Formula | C33H39N11O5S2 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for p-DITC-APEC
Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service
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References for p-DITC-APEC
References are publications that support the biological activity of the product.
Jacobson et al (1992) Chemical modification and irreversible inhibition of striatal A2A adenosine receptors. Mol.Pharmacol. 42 123 PMID: 1635550
Jacobson et al (1989) Agonist derived molecular probes for A2 adenosine receptors. J.Mol.Recog. 2 170
Niiya et al (1993) Covalent binding of a selective agonist irreversibly activates guinea pig coronary artery A2 adenosine receptors. Naunyn-Schmied.Arch.Pharmacol. 347 521
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Keywords: p-DITC-APEC, p-DITC-APEC supplier, A2A, adenosines, agonist, Adenosine, Receptors, 2405, Tocris Bioscience
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