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Biological Activity for Oxotremorine M
Oxotremorine M is a muscarinic receptor agonist. Also directly potentiates NMDA-mediated ion currents.
Technical Data for Oxotremorine M
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Oxotremorine M
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Oxotremorine M
The following data is based on the product molecular weight 322.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.1 mL||15.52 mL||31.04 mL|
|5 mM||0.62 mL||3.1 mL||6.21 mL|
|10 mM||0.31 mL||1.55 mL||3.1 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References for Oxotremorine M
References are publications that support the biological activity of the product.
Birdsall et al (1978) The binding of agonists to brain muscarinic receptors. Mol.Pharmacol. 14 723 PMID: 714021
Kukkonen et al (1996) Functional properties of muscarinic receptor subtypes Hm1, Hm3 and Hm5 expressed in Sf9 cells using the baculovirus expression system. J.Pharmacol.Exp.Ther. 279 593 PMID: 8930161
Zwart et al (2017) Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms. Biochem.Biophys.Res.Commun. 495 481 PMID: 29127015
If you know of a relevant reference for Oxotremorine M, please let us know.
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Keywords: Oxotremorine M, Oxotremorine M supplier, Muscarinic, agonists, Receptors, Acetylcholine, ACh, OxotremorineM, NMDA, potentiator, potentiates, Non-selective, Muscarinics, 1067, Tocris Bioscience
14 Citations for Oxotremorine M
Citations are publications that use Tocris products. Selected citations for Oxotremorine M include:
Wilke et al (2014) Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors. Nat Commun 5 5540 PMID: 25420509
Filippov et al (2010) The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons. PLoS One 30 11068 PMID: 20720114
Narushima et al (2007) Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. J Neurosci 27 496 PMID: 17234582
Ahsan Raza (2017) HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. Nat Commun 8 189 PMID: 28775269
Daigle and Caron (2012) Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation. J Neurosci 32 11461 PMID: 22895728
Buchanan et al (2010) Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels. Neuron 68 948 PMID: 21145007
Abiraman et al (2015) Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair. PLoS One 35 3676 PMID: 25716865
Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Proc Natl Acad Sci U S A 9 284 PMID: 26578914
Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. J Neurosci 112 8124 PMID: 26080439
Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114
Saxena et al (2013) Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival. Neuron 80 80 PMID: 24094105
Won et al (2012) Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS One 7 e42602 PMID: 22880050
Roberts-Crowley and Rittenhouse (2015) Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels. Front Behav Neurosci 10 e0132469 PMID: 26147123
Won et al (2011) Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons. J Neurophysiol 105 442 PMID: 20962070
Do you know of a great paper that uses Oxotremorine M from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.