Muscarinic receptor agonist. Also directly potentiates NMDA-mediated ion currents.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 322.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.1 mL||15.52 mL||31.04 mL|
|5 mM||0.62 mL||3.1 mL||6.21 mL|
|10 mM||0.31 mL||1.55 mL||3.1 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References are publications that support the products' biological activity.
Birdsall et al (1978) The binding of agonists to brain muscarinic receptors. Mol.Pharmacol. 14 723 PMID: 714021
Kukkonen et al (1996) Functional properties of muscarinic receptor subtypes Hm1, Hm3 and Hm5 expressed in Sf9 cells using the baculovirus expression system. J.Pharmacol.Exp.Ther. 279 593 PMID: 8930161
Zwart et al (2017) Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms. Biochem.Biophys.Res.Commun. PMID: 29127015
If you know of a relevant reference for Oxotremorine M, please let us know.
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Keywords: Oxotremorine M, supplier, Muscarinic, agonists, Receptors, Acetylcholine, ACh, OxotremorineM, NMDA, potentiator, potentiates, Non-selective, Muscarinics, NMDA, Receptors, Non-selective, Muscarinics, Tocris Bioscience
9 Citations for Oxotremorine M
Citations are publications that use Tocris products. Selected citations for Oxotremorine M include:
Ahsan Raza (2017) HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. Nat Commun 8 189 PMID: 28775269
Roberts-Crowley and Rittenhouse (2015) Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels. Front Behav Neurosci 10 e0132469 PMID: 26147123
Abiraman et al (2015) Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair. PLoS One 35 3676 PMID: 25716865
Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Proc Natl Acad Sci U S A 9 284 PMID: 26578914
Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. J Neurosci 112 8124 PMID: 26080439
Narushima et al (2007) Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. J Neurosci 27 496 PMID: 17234582
Daigle and Caron (2012) Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation. J Neurosci 32 11461 PMID: 22895728
Buchanan et al (2010) Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels. Neuron 68 948 PMID: 21145007
Filippov et al (2010) The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons. PLoS One 30 11068 PMID: 20720114
Do you know of a great paper that uses Oxotremorine M from Tocris? If so please let us know.
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