[Orn8]-Urotensin II

Discontinued Product

Unfortunately [Orn8]-Urotensin II (Cat. No. 1619) has been withdrawn from sale for commercial reasons.
Cat.No. 1619 - [Orn8]-Urotensin II | Glu-Thr-Pro-Asp-Cys-Phe-Trp-Orn-Tyr-Cys-Val (Disulfide bridge: 5 - 10) | CAS No. 479065-85-5
Description: Urotensin-II (UT) receptor partial agonist
Datasheet
Citations
Literature

Biological Activity

Partial agonist peptide for the urotensin-II (UT) receptor. Acts as a full agonist at recombinant rat and human UT receptors (pEC50 ~ 8) but behaves as a competitive antagonist (pA2 = 6.56) in rat aorta.

Technical Data

M. Wt 1374.54
Formula C63H83N13O18S2
Sequence ETPDCFWXYCV

(Modifications: X = Orn, Disulfide bridge between 5 - 10)

Storage Desiccate at -20°C
CAS Number 479065-85-5
Smiles [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1374.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.73 mL 3.64 mL 7.28 mL
5 mM 0.15 mL 0.73 mL 1.46 mL
10 mM 0.07 mL 0.36 mL 0.73 mL
50 mM 0.01 mL 0.07 mL 0.15 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Camarda et al (2002) A new ligand for the urotensin II receptor. Br.J.Pharmacol. 137 311 PMID: 12237249

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Citations for [Orn8]-Urotensin II

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Currently there are no citations for [Orn8]-Urotensin II.

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Literature in this Area

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Pathways for [Orn8]-Urotensin II

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