[Orn5]-URP

Pricing Availability   Qty
Cat.No. 3162 - [Orn5]-URP | Ala-Cys-Phe-Trp-Orn-Tyr-Cys-Val (Disulfide bridge: 2 - 7) | CAS No. 782485-03-4
Description: Urotensin-II (UT) receptor antagonist
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Urotensin-II (UT) receptor pure antagonist (pEC50 = 7.24). Displays no agonist activity unlike other U-II/URP analogs. Inhibits the action of U-II in the rat aorta ring assay.

Technical Data

M. Wt 1003.2
Formula C48H62N10O10S2
Sequence ACFWXYCV

(Modifications: X = Orn, Disulfide bridge between 2 - 7)

Storage Store at -20°C
CAS Number 782485-03-4
PubChem ID 90488807
InChI Key BPLKRLYKWHXTMO-LSKWFVNGSA-N
Smiles [H]N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Chatenet et al (2004) Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptides 25 1819 PMID: 15476952

Diallo et al (2008) [Orn5]URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes. Peptides 29 813 PMID: 18082287


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Keywords: [Orn5]-URP, [Orn5]-URP supplier, Urotensin-II, UT, receptor, antagonists, Receptors, 3162, Tocris Bioscience

1 Citation for [Orn5]-URP

Citations are publications that use Tocris products. Selected citations for [Orn5]-URP include:

Lee et al (2014) Urotensin II induces interleukin 8 expression in human umbilical vein endothelial cells. PLoS One 9 e90278 PMID: 24587311


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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