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Urotensin-II (UT) receptor pure antagonist (pEC50 = 7.24). Displays no agonist activity unlike other U-II/URP analogs. Inhibits the action of U-II in the rat aorta ring assay.
(Modifications: X = Orn, Disulfide bridge between 2 - 7)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Chatenet et al (2004) Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptides 25 1819 PMID: 15476952
Diallo et al (2008) [Orn5]URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes. Peptides 29 813 PMID: 18082287
If you know of a relevant reference for [Orn5]-URP, please let us know.
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Keywords: [Orn5]-URP, [Orn5]-URP supplier, Urotensin-II, UT, receptor, antagonists, Receptors, 3162, Tocris Bioscience
1 Citation for [Orn5]-URP
Citations are publications that use Tocris products. Selected citations for [Orn5]-URP include:
Lee et al (2014) Urotensin II induces interleukin 8 expression in human umbilical vein endothelial cells. PLoS One 9 e90278 PMID: 24587311
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