[Orn5]-URP

Pricing Availability Delivery Time Qty
Cat.No. 3162 - [Orn5]-URP | Ala-Cys-Phe-Trp-Orn-Tyr-Cys-Val (Disulfide bridge: 2 - 7) | CAS No. 782485-03-4
Description: Urotensin-II (UT) receptor antagonist
Datasheet
Citations (1)
Literature

Biological Activity

Urotensin-II (UT) receptor pure antagonist (pEC50 = 7.24). Displays no agonist activity unlike other U-II/URP analogs. Inhibits the action of U-II in the rat aorta ring assay.

Technical Data

M. Wt 1003.2
Formula C48H62N10O10S2
Sequence ACFWXYCV

(Modifications: X = Orn, Disulfide bridge between 2 - 7)

Storage Store at -20°C
CAS Number 782485-03-4
PubChem ID 90488807
InChI Key BPLKRLYKWHXTMO-LSKWFVNGSA-N
Smiles [H]N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1003.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1 mL 4.98 mL 9.97 mL
5 mM 0.2 mL 1 mL 1.99 mL
10 mM 0.1 mL 0.5 mL 1 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chatenet et al (2004) Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptides 25 1819 PMID: 15476952

Diallo et al (2008) [Orn5]URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes. Peptides 29 813 PMID: 18082287


If you know of a relevant reference for [Orn5]-URP, please let us know.

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Keywords: Urotensin-II UT receptor antagonists Receptors Urotensin-II Receptors

1 Citation for [Orn5]-URP

Citations are publications that use Tocris products. Selected citations for [Orn5]-URP include:

Lee et al (2014) Urotensin II induces interleukin 8 expression in human umbilical vein endothelial cells. PLoS One 9 e90278 PMID: 24587311


Do you know of a great paper that uses [Orn5]-URP from Tocris? If so please let us know.

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Literature in this Area

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Pathways for [Orn5]-URP

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