Org 25543 hydrochloride

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Cat.No. 4782 - Org 25543 hydrochloride | C24H32lN2O4.HCl | CAS No. 495076-64-7
Description: Potent and selective GlyT2 inhibitor
Chemical Name: N-[[1-(Dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)benzamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.

Compound Libraries

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Technical Data

M. Wt 448.98
Formula C24H32lN2O4.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 495076-64-7
PubChem ID 10095215
InChI Key NIPQJILJYQVZJR-UHFFFAOYSA-N
Smiles O=C(NCC2(N(C)C)CCCC2)C1=CC(OC)=C(OCC3=CC=CC=C3)C(OC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.9 100
ethanol 8.98 20
water 8.98 20

Preparing Stock Solutions

The following data is based on the product molecular weight 448.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.14 mL 22.27 mL
5 mM 0.45 mL 2.23 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Caulfield et al (2001) The first potent and selective inhibitors of the glycine transporter type 2. J.Med.Chem. 44 2679 PMID: 11495577

Morita et al (2008) Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J.Pharmacol.Exp.Ther. 326 633 PMID: 18448867


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Keywords: Org25543 hydrochloride glycine transporter type-2 GlyT-2 GlyT2 inhibitors inhibits allodynia pain neuropathic Glycine Transporters

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