Org 25543 hydrochloride

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Description: Potent and selective GlyT2 inhibitor
Chemical Name: N-[[1-(Dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)benzamide hydrochloride
Purity: ≥99% (HPLC)

Biological Activity for Org 25543 hydrochloride

Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.

Compound Libraries for Org 25543 hydrochloride

Org 25543 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Org 25543 hydrochloride

M. Wt 448.98
Formula C24H32lN2O4.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 495076-64-7
PubChem ID 10095215
Smiles O=C(NCC2(N(C)C)CCCC2)C1=CC(OC)=C(OCC3=CC=CC=C3)C(OC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Org 25543 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 8.98 20
DMSO 44.9 100

Preparing Stock Solutions for Org 25543 hydrochloride

The following data is based on the product molecular weight 448.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.14 mL 22.27 mL
5 mM 0.45 mL 2.23 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets for Org 25543 hydrochloride

References for Org 25543 hydrochloride

References are publications that support the biological activity of the product.

Caulfield et al (2001) The first potent and selective inhibitors of the glycine transporter type 2. J.Med.Chem. 44 2679 PMID: 11495577

Morita et al (2008) Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J.Pharmacol.Exp.Ther. 326 633 PMID: 18448867

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Citations for Org 25543 hydrochloride

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