Org 24598 lithium salt

Description: Selective GlyT1 inhibitor
Chemical Name: N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine lithium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective inhibitor of the glial glycine transporter (GlyT1) (pIC50 values are 6.9, <4 and <3 for GlyT1, GABA transporter and Glyt2 respectively).

Technical Data

M. Wt 373.3
Formula C19H19F3LiNO3
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 722456-08-8
PubChem ID 16219807
InChI Key VMQXVSNARQMSDL-UNTBIKODSA-M
Smiles [Li+].CN(CC[C@@H](OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1)CC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Bradaia et al (2004) Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord. J.Physiol. 559 169 PMID: 15235081

Beato (2008) The time course of transmitter at glycinergic synapses onto motoneurons. J.Neurosci. 28 7412 PMID: 18632945

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