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Submit ReviewOrg 24598 lithium salt
Description: Selective GlyT1 inhibitor
Chemical Name: N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine lithium salt
Purity: ≥98% (HPLC)
Biological Activity for Org 24598 lithium salt
Selective inhibitor of the glial glycine transporter (GlyT1) (pIC50 values are 6.9, <4 and <3 for GlyT1, GABA transporter and Glyt2 respectively).
Technical Data for Org 24598 lithium salt
| M. Wt | 373.3 |
| Formula | C19H19F3LiNO3 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 722456-08-8 |
| PubChem ID | 16219807 |
| InChI Key | VMQXVSNARQMSDL-UNTBIKODSA-M |
| Smiles | [Li+].CN(CC[C@@H](OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1)CC([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Org 24598 lithium salt
References for Org 24598 lithium salt
References are publications that support the biological activity of the product.
Bradaia et al (2004) Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord. J.Physiol. 559 169 PMID: 15235081
Beato (2008) The time course of transmitter at glycinergic synapses onto motoneurons. J.Neurosci. 28 7412 PMID: 18632945
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Keywords: Org 24598 lithium salt, Org 24598 lithium salt supplier, Org24598, glial, glycine, transporters, glyt1, selective, inhibitors, inhibits, Glycine, Transporters, 4035, Tocris Bioscience
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