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Selective inhibitor of the glial glycine transporter (GlyT1) (pIC50 values are 6.9, <4 and <3 for GlyT1, GABA transporter and Glyt2 respectively).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Bradaia et al (2004) Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord. J.Physiol. 559 169 PMID: 15235081
Beato (2008) The time course of transmitter at glycinergic synapses onto motoneurons. J.Neurosci. 28 7412 PMID: 18632945
Keywords: Org 24598 lithium salt, Org 24598 lithium salt supplier, Org24598, glial, glycine, transporters, glyt1, selective, inhibitors, inhibits, Glycine, Transporters, 4035, Tocris Bioscience
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.