Org 24598

Pricing Availability   Qty
Description: Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo
Chemical Name: N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for Org 24598

Org 24598 is a potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 < 4). Active in vivo.

Technical Data for Org 24598

M. Wt 367.36
Formula C19H20F3NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 372198-97-5
PubChem ID 5311285
Smiles CN(CC(O)=O)CC[C@@H](OC2=CC=C(C(F)(F)F)C=C2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Org 24598

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.74 100

Preparing Stock Solutions for Org 24598

The following data is based on the product molecular weight 367.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.61 mL 27.22 mL
5 mM 0.54 mL 2.72 mL 5.44 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Org 24598

Certificate of Analysis / Product Datasheet
Select another batch:

References for Org 24598

References are publications that support the biological activity of the product.

Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID: 23194655

Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 11 2007 PMID: 11454468

Williams et al (2003) Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity. Anal. Biochem. 321 31 PMID: 12963052

If you know of a relevant reference for Org 24598, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Glycine Transporter Inhibitors

Keywords: Org 24598, Org 24598 supplier, Org24598, glial, glycine, transporters, glyt1, inhibitors, inhibits, Glycine, Transporters, 4447, Tocris Bioscience

1 Citation for Org 24598

Citations are publications that use Tocris products. Selected citations for Org 24598 include:

Jaekwang et al (2020) The molecular mechanism of synaptic activity-induced astrocytic volume transient. J Physiol 598 4555-4572 PMID: 32706443

Do you know of a great paper that uses Org 24598 from Tocris? Please let us know.

Reviews for Org 24598

There are currently no reviews for this product. Be the first to review Org 24598 and earn rewards!

Have you used Org 24598?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review