Inhibitor of the glial glycine transporter (GlyT1); derivative of Org 24598 (Cat. No. 4035).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||3.67||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 367.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.72 mL||13.61 mL||27.22 mL|
|5 mM||0.54 mL||2.72 mL||5.44 mL|
|10 mM||0.27 mL||1.36 mL||2.72 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References are publications that support the products' biological activity.
Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID: 23194655
Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 11 2007 PMID: 11454468
If you know of a relevant reference for Org 24598, please let us know.
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Keywords: Org 24598, supplier, Org24598, glial, glycine, transporters, glyt1, inhibitors, inhibits, Glycine, Transporters, Glycine, Transporters, Tocris Bioscience
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Literature in this Area
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.