Org 24598

Pricing Availability Delivery Time Qty
Cat.No. 4447 - Org 24598 | C19H20F3NO3 | CAS No. 372198-97-5
Description: Inhibitor of GlyT1; derivative of Org 24598 (Cat. No. 4035).
Chemical Name: N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of the glial glycine transporter (GlyT1); derivative of Org 24598 (Cat. No. 4035).

Technical Data

M. Wt 367.36
Formula C19H20F3NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 372198-97-5
PubChem ID 5311285
InChI Key KZWQAWBTWNPFPW-QGZVFWFLSA-N
Smiles CN(CC(O)=O)CC[C@@H](OC2=CC=C(C(F)(F)F)C=C2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.74 100
water 3.67 10mM with gentle warming
water 18.37 50

Preparing Stock Solutions

The following data is based on the product molecular weight 367.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.61 mL 27.22 mL
5 mM 0.54 mL 2.72 mL 5.44 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID: 23194655

Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 11 2007 PMID: 11454468


If you know of a relevant reference for Org 24598, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Glycine Transporter Inhibitors

Keywords: Org 24598, supplier, Org24598, glial, glycine, transporters, glyt1, inhibitors, inhibits, Glycine, Transporters, Tocris Bioscience

Citations for Org 24598

Citations are publications that use Tocris products.

Currently there are no citations for Org 24598. Do you know of a great paper that uses Org 24598 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Pathways for Org 24598

Protocols

TODO: Add Protocols