Opicapone

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Description: COMT inhibitor
Chemical Name: 5-[3-(2,5-Dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-1,2-benzenediol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for Opicapone

Opicapone is a reversible catechol O-methyltransferase inhibitor (COMT) inhibitor (IC50 = 224 nM). Decreases the ATP content and mitochondrial membrane potential in cells (IC50 values are 98 μM and 181 μM respectively). When administered with L-DOPA (Cat. No. 3788) it attenuates Parkinson's-like symptoms in an MPTP-induced animal model.

Technical Data for Opicapone

M. Wt 413.17
Formula C15H10Cl2N4O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 923287-50-7
PubChem ID 135565903
InChI Key ASOADIZOVZTJSR-UHFFFAOYSA-N
Smiles OC1=CC(C2=NC(C3=C(C(Cl)=C([N+]([O-])=C3Cl)C)C)=NO2)=CC([N+]([O-])=O)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Opicapone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.32 100

Preparing Stock Solutions for Opicapone

The following data is based on the product molecular weight 413.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.1 mL 24.2 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References for Opicapone

References are publications that support the biological activity of the product.

Ettcheto et al (2020) The preclinical discovery and development of opicapone for the treatment of Parkinson's disease. Expert Opin.Drug Discov. 15 993 PMID: 32450711

Bonifácio et al (2021) Opicapone enhances the reversal of MPTP-induced Parkinson-like syndrome by levodopa in cynomolgus monkeys. Eur.J.Pharmacol. 892 173742 PMID: 33220276


If you know of a relevant reference for Opicapone, please let us know.

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Keywords: Opicapone, Opicapone supplier, comt, inhibitors, catechol-O-methytransferases, mitochondrial, membrane, potential, ATP, LDOPA, levodopa, Parkinsons, Catechol, O-Methyltransferase, 7668, Tocris Bioscience

Citations for Opicapone

Citations are publications that use Tocris products.

Currently there are no citations for Opicapone. Do you know of a great paper that uses Opicapone from Tocris? Please let us know.

Reviews for Opicapone

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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