ONO 8130

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Description: EP1 receptor antagonist
Chemical Name: 4-[[[2,3-Dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-indene-5yl]oxy]methyl]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for ONO 8130

ONO 8130 is an EP1 receptor antagonist. Exhibits analgesic effect in a mouse model of cystitis. Orally bioavailable.

Compound Libraries for ONO 8130

ONO 8130 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ONO 8130

M. Wt 500.63
Formula C25H28N2O5S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 459841-96-4
PubChem ID 9827317
InChI Key IOXMDBQCUCDLAF-UHFFFAOYSA-N
Smiles CC(C)CN(S(C3=NC(C)=CS3)(=O)=O)C1=C(OCC4=CC=C(C(O)=O)C=C4)C=C(CCC2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ONO 8130

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.06 100
ethanol 10.01 20

Preparing Stock Solutions for ONO 8130

The following data is based on the product molecular weight 500.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.97 mL
5 mM 0.4 mL 2 mL 3.99 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for ONO 8130

References are publications that support the biological activity of the product.

Miki et al (2011) ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain 152 1373 PMID: 21396778

Lipina et al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to cloz. in mouse models of schizophrenia. Psychopharmacology 179 54 PMID: 15759151


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Keywords: ONO 8130, ONO 8130 supplier, ONO8130, EP1, receptor, antagonists, antagonism, analgesics, cystitis, Prostanoid, Receptors, 5406, Tocris Bioscience

1 Citation for ONO 8130

Citations are publications that use Tocris products. Selected citations for ONO 8130 include:

Petra I et al (2022) NR5A2/LRH-1 regulates the PTGS2-PGE2-PTGER1 pathway contributing to pancreatic islet survival and function. iScience 25 104345 PMID: 35602948


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