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Biological Activity for ONO 8130
ONO 8130 is an EP1 receptor antagonist. Exhibits analgesic effect in a mouse model of cystitis. Orally bioavailable.
Compound Libraries for ONO 8130
Technical Data for ONO 8130
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ONO 8130
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ONO 8130
The following data is based on the product molecular weight 500.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2 mL||9.99 mL||19.97 mL|
|5 mM||0.4 mL||2 mL||3.99 mL|
|10 mM||0.2 mL||1 mL||2 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References for ONO 8130
References are publications that support the biological activity of the product.
Miki et al (2011) ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain 152 1373 PMID: 21396778
Lipina et al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to cloz. in mouse models of schizophrenia. Psychopharmacology 179 54 PMID: 15759151
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Keywords: ONO 8130, ONO 8130 supplier, ONO8130, EP1, receptor, antagonists, antagonism, analgesics, cystitis, Prostanoid, Receptors, 5406, Tocris Bioscience
1 Citation for ONO 8130
Citations are publications that use Tocris products. Selected citations for ONO 8130 include:
Petra I et al (2022) NR5A2/LRH-1 regulates the PTGS2-PGE2-PTGER1 pathway contributing to pancreatic islet survival and function. iScience 25 104345 PMID: 35602948
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