ONO 8130

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Cat.No. 5406 - ONO 8130 | C25H28N2O5S2 | CAS No. 459841-96-4
Description: EP1 receptor antagonist
Chemical Name: 4-[[[2,3-Dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-indene-5yl]oxy]methyl]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

EP1 receptor antagonist. Exhibits analgesic effect in a mouse mode of cystitis. Orally bioavailable.

Compound Libraries

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Technical Data

M. Wt 500.63
Formula C25H28N2O5S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 459841-96-4
PubChem ID 9827317
InChI Key IOXMDBQCUCDLAF-UHFFFAOYSA-N
Smiles CC(C)CN(S(C3=NC(C)=CS3)(=O)=O)C1=C(OCC4=CC=C(C(O)=O)C=C4)C=C(CCC2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.06 100
ethanol 10.01 20

Preparing Stock Solutions

The following data is based on the product molecular weight 500.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.97 mL
5 mM 0.4 mL 2 mL 3.99 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Miki et al (2011) ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain 152 1373 PMID: 21396778

Lipina et al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia. Psychopharmacology 179 54 PMID: 15759151


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Keywords: ONO 8130, supplier, ONO8130, EP1, receptor, antagonists, antagonism, analgesics, cystitis, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience

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