Selective 5-HT3 receptor antagonist (Ki = 6.16 nM). Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 329.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.03 mL||15.16 mL||30.32 mL|
|5 mM||0.61 mL||3.03 mL||6.06 mL|
|10 mM||0.3 mL||1.52 mL||3.03 mL|
|50 mM||0.06 mL||0.3 mL||0.61 mL|
References are publications that support the products' biological activity.
Youssefyeh et al (1992) Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. J.Med.Chem. 35 895 PMID: 1312602
Ye et al (2001) Ondansetron: a selective 5-HT3 receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 7 199 PMID: 11474424
Ginawi et al (2005) Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice. Pharmacol.Res. 51 255 PMID: 15661576
If you know of a relevant reference for Ondansetron hydrochloride, please let us know.
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Keywords: Ondansetron hydrochloride, supplier, Selective, 5-HT3, antagonists, Serotonin, Receptors, GR38032, GR, 38032, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience
2 Citations for Ondansetron hydrochloride
Citations are publications that use Tocris products. Selected citations for Ondansetron hydrochloride include:
Pezeshki et al (2016) Low protein diets produce divergent effects on energy balance. PLoS One 6 25145 PMID: 27122299
Amorim et al (2015) Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. Antioxid Redox Signal 10 e0142919 PMID: 26565961
Do you know of a great paper that uses Ondansetron hydrochloride from Tocris? If so please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.