Ondansetron hydrochloride

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Cat.No. 2891 - Ondansetron hydrochloride | C18H19N3O.HCl | CAS No. 99614-01-4
Description: Selective 5-HT3 antagonist
Alternative Names: GR 38032
Chemical Name: 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride
Purity: ≥99% (HPLC)
Citations (5)
Literature (2)

Biological Activity for Ondansetron hydrochloride

Ondansetron hydrochloride is a selective 5-HT3 receptor antagonist (Ki = 6.16 nM). Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.

Technical Data for Ondansetron hydrochloride

M. Wt 329.83
Formula C18H19N3O.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 99614-01-4
PubChem ID 68647
Smiles CN1C3=C(C=CC=C3)C2=C1CCC(CN4C(C)=NC=C4)C2=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ondansetron hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 16.49 50
DMSO 32.98 100

Preparing Stock Solutions for Ondansetron hydrochloride

The following data is based on the product molecular weight 329.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.16 mL 30.32 mL
5 mM 0.61 mL 3.03 mL 6.06 mL
10 mM 0.3 mL 1.52 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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Product Datasheets for Ondansetron hydrochloride

Certificate of Analysis / Product Datasheet
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References for Ondansetron hydrochloride

References are publications that support the biological activity of the product.

Youssefyeh et al (1992) Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. J.Med.Chem. 35 895 PMID: 1312602

Ye et al (2001) Ondansetron: a selective 5-HT3 receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 7 199 PMID: 11474424

Ginawi et al (2005) Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice. Pharmacol.Res. 51 255 PMID: 15661576

If you know of a relevant reference for Ondansetron hydrochloride, please let us know.

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Keywords: Ondansetron hydrochloride, Ondansetron hydrochloride supplier, Selective, 5-HT3, antagonists, Serotonin, Receptors, GR38032, GR, 38032, 2891, Tocris Bioscience

5 Citations for Ondansetron hydrochloride

Citations are publications that use Tocris products. Selected citations for Ondansetron hydrochloride include:

Capasso et al (2012) Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects. Br J Pharmacol 165 1966 PMID: 21955242

Spring et al (2019) Methionine Restriction Partly Recapitulates the Sympathetically Mediated Enhanced Energy Expenditure Induced by Total Amino Acid Restriction in Rats. Nutrients 11 PMID: 30917593

Amorim et al (2015) Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. Antioxid Redox Signal 10 e0142919 PMID: 26565961

Pezeshki et al (2016) Low protein diets produce divergent effects on energy balance. PLoS One 6 25145 PMID: 27122299

Do you know of a great paper that uses Ondansetron hydrochloride from Tocris? Please let us know.

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Literature in this Area

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5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.