Ondansetron hydrochloride

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Cat.No. 2891 - Ondansetron hydrochloride | C18H19N3O.HCl | CAS No. 99614-01-4
Description: Selective 5-HT3 antagonist
Alternative Names: GR 38032
Chemical Name: 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

Selective 5-HT3 receptor antagonist (Ki = 6.16 nM). Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.

Technical Data

M. Wt 329.83
Formula C18H19N3O.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 99614-01-4
PubChem ID 68647
InChI Key MKBLHFILKIKSQM-UHFFFAOYSA-N
Smiles CN1C3=C(C=CC=C3)C2=C1CCC(CN4C(C)=NC=C4)C2=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.49 50
DMSO 32.98 100

Preparing Stock Solutions

The following data is based on the product molecular weight 329.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.16 mL 30.32 mL
5 mM 0.61 mL 3.03 mL 6.06 mL
10 mM 0.3 mL 1.52 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Youssefyeh et al (1992) Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. J.Med.Chem. 35 895 PMID: 1312602

Ye et al (2001) Ondansetron: a selective 5-HT3 receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 7 199 PMID: 11474424

Ginawi et al (2005) Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice. Pharmacol.Res. 51 255 PMID: 15661576


If you know of a relevant reference for Ondansetron hydrochloride, please let us know.

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Keywords: Ondansetron hydrochloride, Ondansetron hydrochloride supplier, Selective, 5-HT3, antagonists, Serotonin, Receptors, GR38032, GR, 38032, 2891, Tocris Bioscience

4 Citations for Ondansetron hydrochloride

Citations are publications that use Tocris products. Selected citations for Ondansetron hydrochloride include:

Amorim et al (2015) Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. Antioxid Redox Signal 10 e0142919 PMID: 26565961

Jin et al (2014) Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons. Korean J Physiol Pharmacol 18 149 PMID: 24757377

Pezeshki et al (2016) Low protein diets produce divergent effects on energy balance. PLoS One 6 25145 PMID: 27122299

Capasso et al (2012) Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects. Br J Pharmacol 165 1966 PMID: 21955242


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.