Home / Pharmacology / 7-TM Receptors / GPBA Receptors / GPBA Receptor Agonists / Oleanolic acid

Oleanolic acid

Cat. No. 6026 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 6026 - Oleanolic acid | C30H48O3 | CAS No. 508-02-1
Description: Selective GPBA receptor (TGR5) partial agonist
Chemical Name: (3β)-3-Hydroxyolean-12-en-28-oic acid
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

GPBA receptor (TGR5) partial agonist (EC50 = 2.25 μM; 72% efficacy). Displays no activity at FXR. Also inhibits protein phosphate 1B (PTP1B) and glycogen phosphorylase. Suppresses cell proliferation and increases apoptosis in T24 bladder cancer cells. Antidiabetic, antihyperglycaemic, antitumor and hepatoprotective.

Technical Data

M. Wt 456.7
Formula C30H48O3
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 508-02-1
PubChem ID 10494
InChI Key MIJYXULNPSFWEK-GTOFXWBISA-N
Smiles [H][C@@]12CC(C)(CC[C@]1(C(O)=O)CC[C@@]3(C2=CC[C@@]4([C@]5(CC[C@@H](C(C)([C@@]5(CC[C@@]34C)[H])C)O)C)[H])C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.13 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 456.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.95 mL 54.74 mL 109.48 mL
1 mM 2.19 mL 10.95 mL 21.9 mL
2 mM 1.09 mL 5.47 mL 10.95 mL
10 mM 0.22 mL 1.09 mL 2.19 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Genet et al (2010) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 53 178 PMID: 19911773

Mu et al (2015) Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling. Int.J.Clin.Exp.Pathol. 8 13864 PMID: 26823699

Castellano et al (2013) Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes. Diabetes 62 1791 PMID: 23704520

If you know of a relevant reference for Oleanolic acid, please let us know.

View Related Products by Target

View Related Products by Product Action

View all GPBA Receptor Agonists

Keywords: Oleanolic acid, Oleanolic acid supplier, Natural, triterpenoids, TGR5, partial, agonists, agonism, protein, phosphate, 1B, PTP1B, inhibitors, inhibits, glycogen, phosphorylases, antidiabetic,, antihyperglycaemic, antitumor, hepatoprotective, apoptosis, inducers, cell, proliferation, GPBA, Receptors, Phosphorylases, Apoptosis, Inducers, 6026, Tocris Bioscience

Citations for Oleanolic acid

Citations are publications that use Tocris products.

Currently there are no citations for Oleanolic acid. Do you know of a great paper that uses Oleanolic acid from Tocris? Please let us know.

Reviews for Oleanolic acid

There are currently no reviews for this product. Be the first to review Oleanolic acid and earn rewards!

Have you used Oleanolic acid?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pathways for Oleanolic acid

Insulin

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.