GPBA receptor (TGR5) partial agonist (EC50 = 2.25 μM; 72% efficacy). Displays no activity at FXR. Also inhibits protein phosphate 1B (PTP1B) and glycogen phosphorylase. Suppresses cell proliferation and increases apoptosis in T24 bladder cancer cells. Antidiabetic, antihyperglycaemic, antitumor and hepatoprotective.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||9.13||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 456.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.95 mL||54.74 mL||109.48 mL|
|1 mM||2.19 mL||10.95 mL||21.9 mL|
|2 mM||1.09 mL||5.47 mL||10.95 mL|
|10 mM||0.22 mL||1.09 mL||2.19 mL|
References are publications that support the biological activity of the product.
Genet et al (2010) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 53 178 PMID: 19911773
Mu et al (2015) Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling. Int.J.Clin.Exp.Pathol. 8 13864 PMID: 26823699
Castellano et al (2013) Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes. Diabetes 62 1791 PMID: 23704520
If you know of a relevant reference for Oleanolic acid, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Oleanolic acid, Oleanolic acid supplier, Natural, triterpenoids, TGR5, partial, agonists, agonism, protein, phosphate, 1B, PTP1B, inhibitors, inhibits, glycogen, phosphorylases, antidiabetic,, antihyperglycaemic, antitumor, hepatoprotective, apoptosis, inducers, cell, proliferation, GPBA, Receptors, Phosphorylases, Apoptosis, Inducers, 6026, Tocris Bioscience
Citations for Oleanolic acid
Citations are publications that use Tocris products.
Currently there are no citations for Oleanolic acid. Do you know of a great paper that uses Oleanolic acid from Tocris? Please let us know.
Reviews for Oleanolic acid
There are currently no reviews for this product. Be the first to review Oleanolic acid and earn rewards!
Have you used Oleanolic acid?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.