Oleamide

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Cat.No. 0878 - Oleamide | C18H35NO | CAS No. 301-02-0
Description: Sleep-inducing brain lipid
Chemical Name: cis-9-Octadecenamide
Purity: ≥98%
Datasheet
Citations
Reviews
Literature

Biological Activity

Endogenous sleep-inducing lipid. Acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Also appears to potentiate the actions of 5-HT on 5-HT2A and 2C receptors, and act via an allosteric regulatory site on 5-HT7 receptors.

Technical Data

M. Wt 281.48
Formula C18H35NO
Storage Store at +4°C
Purity ≥98%
CAS Number 301-02-0
PubChem ID 5283387
InChI Key FATBGEAMYMYZAF-KTKRTIGZSA-N
Smiles CCCCCCCC\C=C/CCCCCCCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 28.15 100
DMSO 14.07 50

Preparing Stock Solutions

The following data is based on the product molecular weight 281.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.55 mL 17.76 mL 35.53 mL
5 mM 0.71 mL 3.55 mL 7.11 mL
10 mM 0.36 mL 1.78 mL 3.55 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Cravatt et al (1995) Chemical characterisation of a family of brain lipids that induces sleep. Science 268 1506 PMID: 7770779

Hedlund et al (1999) Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem.Pharmacol. 58 1807 PMID: 10571256

Huidobro-Toro and Harris (1996) Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors. Proc.Natl.Acad.Sci.U.S.A. 93 8078 PMID: 8755606

Leggett et al (2004) Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. Br.J.Pharmacol. 141 253 PMID: 14707029


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Keywords: Oleamide, Oleamide supplier, Sleep-inducing, brain, lipid, Potentiator, 5-HT2A, 5-HT2C, receptors, CB1, agonists, Lipid, Metabolism, Serotonin, 5-Hydroxytryptamine, Cannabinoid, cb1r, 5-HT-Related, Receptors, Other, 0878, Tocris Bioscience

Citations for Oleamide

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Literature in this Area

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