Oleamide

Pricing Availability Delivery Time Qty
Cat.No. 0878 - Oleamide | C18H35NO | CAS No. 301-02-0
Description: Sleep-inducing brain lipid
Chemical Name: cis-9-Octadecenamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Endogenous sleep-inducing lipid. Acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Also appears to potentiate the actions of 5-HT on 5-HT2A and 2C receptors, and act via an allosteric regulatory site on 5-HT7 receptors.

Technical Data

M. Wt 281.48
Formula C18H35NO
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 301-02-0
PubChem ID 5283387
InChI Key FATBGEAMYMYZAF-KTKRTIGZSA-N
Smiles CCCCCCCC\C=C/CCCCCCCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.07 50
ethanol 28.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 281.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.55 mL 17.76 mL 35.53 mL
5 mM 0.71 mL 3.55 mL 7.11 mL
10 mM 0.36 mL 1.78 mL 3.55 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cravatt et al (1995) Chemical characterisation of a family of brain lipids that induces sleep. Science 268 1506 PMID: 7770779

Hedlund et al (1999) Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem.Pharmacol. 58 1807 PMID: 10571256

Huidobro-Toro and Harris (1996) Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors. Proc.Natl.Acad.Sci.U.S.A. 93 8078 PMID: 8755606

Leggett et al (2004) Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. Br.J.Pharmacol. 141 253 PMID: 14707029


If you know of a relevant reference for Oleamide, please let us know.

Keywords: Sleep-inducing brain lipid Potentiator 5-HT2A 5-HT2C receptors CB1 agonists Lipid Metabolism Serotonin 5-Hydroxytryptamine Cannabinoid cb1r Other Lipid Metabolism

Citations for Oleamide

Citations are publications that use Tocris products.

Currently there are no citations for Oleamide. Do you know of a great paper that uses Oleamide from Tocris? If so please let us know.

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Oleamide

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