Oleamide

Discontinued Product

Oleamide (Cat. No. 0878) has been withdrawn from sale for commercial reasons.
Description: Sleep-inducing brain lipid
Chemical Name: cis-9-Octadecenamide
Purity: ≥98%
Datasheet
Citations
Reviews

Biological Activity for Oleamide

Oleamide is an endogenous sleep-inducing lipid. Acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Also appears to potentiate the actions of 5-HT on 5-HT2A and 2C receptors, and act via an allosteric regulatory site on 5-HT7 receptors.

Technical Data for Oleamide

M. Wt 281.48
Formula C18H35NO
Storage Store at +4°C
Purity ≥98%
CAS Number 301-02-0
PubChem ID 5283387
InChI Key FATBGEAMYMYZAF-KTKRTIGZSA-N
Smiles CCCCCCCC\C=C/CCCCCCCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Oleamide

Certificate of Analysis / Product Datasheet
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References for Oleamide

References are publications that support the biological activity of the product.

Cravatt et al (1995) Chemical characterisation of a family of brain lipids that induces sleep. Science 268 1506 PMID: 7770779

Hedlund et al (1999) Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem.Pharmacol. 58 1807 PMID: 10571256

Huidobro-Toro and Harris (1996) Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors. Proc.Natl.Acad.Sci.U.S.A. 93 8078 PMID: 8755606

Leggett et al (2004) Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. Br.J.Pharmacol. 141 253 PMID: 14707029

Keywords: Oleamide, Oleamide supplier, Sleep-inducing, brain, lipid, Potentiator, 5-HT2A, 5-HT2C, receptors, CB1, agonists, Lipid, Metabolism, Serotonin, 5-Hydroxytryptamine, Cannabinoid, cb1r, 5-HT-Related, Receptors, Other, 0878, Tocris Bioscience

Citations for Oleamide

Citations are publications that use Tocris products.

Currently there are no citations for Oleamide.

Reviews for Oleamide

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