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Submit ReviewOleamide
Description: Sleep-inducing brain lipid
Chemical Name: cis-9-Octadecenamide
Purity: ≥98%
Biological Activity for Oleamide
Oleamide is an endogenous sleep-inducing lipid. Acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Also appears to potentiate the actions of 5-HT on 5-HT2A and 2C receptors, and act via an allosteric regulatory site on 5-HT7 receptors.
Technical Data for Oleamide
| M. Wt | 281.48 |
| Formula | C18H35NO |
| Storage | Store at +4°C |
| Purity | ≥98% |
| CAS Number | 301-02-0 |
| PubChem ID | 5283387 |
| InChI Key | FATBGEAMYMYZAF-KTKRTIGZSA-N |
| Smiles | CCCCCCCC\C=C/CCCCCCCC(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Oleamide
References for Oleamide
References are publications that support the biological activity of the product.
Cravatt et al (1995) Chemical characterisation of a family of brain lipids that induces sleep. Science 268 1506 PMID: 7770779
Hedlund et al (1999) Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem.Pharmacol. 58 1807 PMID: 10571256
Huidobro-Toro and Harris (1996) Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors. Proc.Natl.Acad.Sci.U.S.A. 93 8078 PMID: 8755606
Leggett et al (2004) Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. Br.J.Pharmacol. 141 253 PMID: 14707029
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Keywords: Oleamide, Oleamide supplier, Sleep-inducing, brain, lipid, Potentiator, 5-HT2A, 5-HT2C, receptors, CB1, agonists, Lipid, Metabolism, Serotonin, 5-Hydroxytryptamine, Cannabinoid, cb1r, 5-HT-Related, Receptors, Other, 0878, Tocris Bioscience
Citations for Oleamide
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Currently there are no citations for Oleamide.
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