Ogerin

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Cat.No. 5722 - Ogerin | C17H17N5O | CAS No. 1309198-71-7
Description: Selective positive allosteric modulator at GPR68
Chemical Name: 2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective positive allosteric modulator at GPR68 (pEC50 = 6.83). Exhibits selectivity for GPR68 over 58 other GPCRs. Attenuates contextual-based fear memory in mice.

Technical Data

M. Wt 307.35
Formula C17H17N5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1309198-71-7
PubChem ID 56707820
InChI Key MDGIEDNDSFMSLP-UHFFFAOYSA-N
Smiles NC1=NC(NCC2=CC=CC=C2)=NC(C3=CC=CC=C3CO)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.73 100
ethanol 6.15 20

Preparing Stock Solutions

The following data is based on the product molecular weight 307.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Huang et al (2015) Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature 527 477 PMID: 26550826


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Citations for Ogerin

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Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pathways for Ogerin

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