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Biological Activity for Ogerin
Ogerin is a selective positive allosteric modulator (PAM) of GPR68 (pEC50 = 6.83), which exhibits selectivity for GPR68 over 58 other GPCRs. Ogerin attenuates contextual-based fear memory in mice.
External Portal Information for Ogerin
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of Ogerin is reviewed on chemicalprobes.org and the SGC website.
Compound Libraries for Ogerin
Technical Data for Ogerin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ogerin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Ogerin
The following data is based on the product molecular weight 307.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.25 mL||16.27 mL||32.54 mL|
|5 mM||0.65 mL||3.25 mL||6.51 mL|
|10 mM||0.33 mL||1.63 mL||3.25 mL|
|50 mM||0.07 mL||0.33 mL||0.65 mL|
References for Ogerin
References are publications that support the biological activity of the product.
Huang et al (2015) Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature 527 477 PMID: 26550826
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Keywords: Ogerin, Ogerin supplier, positive, allosteric, modulators, GPR68, selective, learning, memory, PAM, Orphan, 7-TM, Receptors, 5722, Tocris Bioscience
Citations for Ogerin
Citations are publications that use Tocris products.
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Reviews for Ogerin
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Literature in this Area
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