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Description: Selective positive allosteric modulator at GPR68
Chemical Name: 2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol
Purity: ≥98% (HPLC)

Biological Activity for Ogerin

Ogerin is a selective positive allosteric modulator (PAM) of GPR68 (pEC50 = 6.83), which exhibits selectivity for GPR68 over 58 other GPCRs. Ogerin attenuates contextual-based fear memory in mice.

External Portal Information for Ogerin

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of Ogerin is reviewed on chemicalprobes.org and the SGC website.

Compound Libraries for Ogerin

Ogerin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ogerin

M. Wt 307.35
Formula C17H17N5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1309198-71-7
PubChem ID 56707820
Smiles NC1=NC(NCC2=CC=CC=C2)=NC(C3=CC=CC=C3CO)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ogerin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.73 100
ethanol 6.15 20

Preparing Stock Solutions for Ogerin

The following data is based on the product molecular weight 307.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets for Ogerin

Certificate of Analysis / Product Datasheet
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References for Ogerin

References are publications that support the biological activity of the product.

Huang et al (2015) Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature 527 477 PMID: 26550826

If you know of a relevant reference for Ogerin, please let us know.

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Keywords: Ogerin, Ogerin supplier, positive, allosteric, modulators, GPR68, selective, learning, memory, PAM, Orphan, 7-TM, Receptors, 5722, Tocris Bioscience

Citations for Ogerin

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