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Selective positive allosteric modulator at GPR68 (pEC50 = 6.83). Exhibits selectivity for GPR68 over 58 other GPCRs. Attenuates contextual-based fear memory in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 307.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.25 mL||16.27 mL||32.54 mL|
|5 mM||0.65 mL||3.25 mL||6.51 mL|
|10 mM||0.33 mL||1.63 mL||3.25 mL|
|50 mM||0.07 mL||0.33 mL||0.65 mL|
References are publications that support the biological activity of the product.
Huang et al (2015) Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature 527 477 PMID: 26550826
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Keywords: Ogerin, Ogerin supplier, positive, allosteric, modulators, GPR68, selective, learning, memory, PAM, Orphan, 7-TM, Receptors, 5722, Tocris Bioscience
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