OBAA

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Cat.No. 0606 - OBAA | C28H44O3 | CAS No. 221632-26-4
Description: Phospholipase A2 inhibitor
Chemical Name: 4-(4-Octadecylphenyl)-4-oxobutenoic acid
Datasheet
Citations (1)
Literature

Biological Activity

A potent inhibitor of phospholipase A2 (IC50 = 70 nM). Reduces bronchospasm in guinea pigs in vivo.

Technical Data

M. Wt 428.65
Formula C28H44O3
Storage Desiccate at +4°C
CAS Number 221632-26-4
PubChem ID 5353842
InChI Key ZBESASFHIWDSCJ-WCWDXBQESA-N
Smiles CCCCCCCCCCCCCCCCCCC1=CC=C(C=C1)C(=O)\C=C\C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.29 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 428.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.66 mL 23.33 mL
5 mM 0.47 mL 2.33 mL 4.67 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kohler et al (1991) Phospholipase-A2 inhibition by alkylbenzoyl acrylic acids. Agents Actions 32 70 PMID: 2058477

Kohler et al (1992) Phospholipase A2 inhibition by alkylbenzoyl acrylic acids. Biochem.Pharmacol. 44 805 PMID: 1324685

Madi et al (1991) Allergen-induced bronchospasm in passively sensitized guinea-pigs - influence of new substances in comparison to reference compounds. Agents Actions 32 144 PMID: 2058463


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Keywords: OBAA, supplier, Phospholipases, A2, inhibitors, inhibits, PLA, sPLA2, Esterases, Phospholipases, Tocris Bioscience

1 Citation for OBAA

Citations are publications that use Tocris products. Selected citations for OBAA include:

Bianca et al (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Nat Commun 161 1835 PMID: 20825409


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Pathways for OBAA

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