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Cat.No. 0606 - OBAA | C28H44O3 | CAS No. 221632-26-4
Description: Phospholipase A2 inhibitor
Chemical Name: 4-(4-Octadecylphenyl)-4-oxobutenoic acid
Citations (1)
Reviews (1)

Biological Activity

A potent inhibitor of phospholipase A2 (IC50 = 70 nM). Reduces bronchospasm in guinea pigs in vivo.

Technical Data

M. Wt 428.65
Formula C28H44O3
Storage Desiccate at +4°C
CAS Number 221632-26-4
PubChem ID 5353842

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.29 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 428.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.66 mL 23.33 mL
5 mM 0.47 mL 2.33 mL 4.67 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Kohler et al (1991) Phospholipase-A2 inhibition by alkylbenzoyl acrylic acids. Agents Actions 32 70 PMID: 2058477

Kohler et al (1992) Phospholipase A2 inhibition by alkylbenzoyl acrylic acids. Biochem.Pharmacol. 44 805 PMID: 1324685

Madi et al (1991) Allergen-induced bronchospasm in passively sensitized guinea-pigs - influence of new substances in comparison to reference compounds. Agents Actions 32 144 PMID: 2058463

If you know of a relevant reference for OBAA, please let us know.

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Keywords: OBAA, supplier, Phospholipases, A2, inhibitors, inhibits, PLA, sPLA2, Esterases, Phospholipases, Phospholipases, Tocris Bioscience

1 Citation for OBAA

Citations are publications that use Tocris products. Selected citations for OBAA include:

Bianca et al (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Nat Commun 161 1835 PMID: 20825409

Do you know of a great paper that uses OBAA from Tocris? If so please let us know.

Reviews for OBAA

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used this drug as an inhibitor
By Anonymous on 10/05/2017
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: macrophages

Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation

review image

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