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Biological Activity for OBAA
OBAA is a potent inhibitor of phospholipase A2 (IC50 = 70 nM). Reduces bronchospasm in guinea pigs in vivo.
Technical Data for OBAA
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for OBAA
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||4.29||10 with gentle warming|
Preparing Stock Solutions for OBAA
The following data is based on the product molecular weight 428.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||23.33 mL||116.65 mL||233.29 mL|
|0.5 mM||4.67 mL||23.33 mL||46.66 mL|
|1 mM||2.33 mL||11.66 mL||23.33 mL|
|5 mM||0.47 mL||2.33 mL||4.67 mL|
References for OBAA
References are publications that support the biological activity of the product.
Kohler et al (1991) Phospholipase-A2 inhibition by alkylbenzoyl acrylic acids. Agents Actions 32 70 PMID: 2058477
Kohler et al (1992) Phospholipase A2 inhibition by alkylbenzoyl acrylic acids. Biochem.Pharmacol. 44 805 PMID: 1324685
Madi et al (1991) Allergen-induced bronchospasm in passively sensitized guinea-pigs - influence of new substances in comparison to reference compounds. Agents Actions 32 144 PMID: 2058463
If you know of a relevant reference for OBAA, please let us know.
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Keywords: OBAA, OBAA supplier, Phospholipases, A2, inhibitors, inhibits, PLA, sPLA2, Esterases, 0606, Tocris Bioscience
2 Citations for OBAA
Citations are publications that use Tocris products. Selected citations for OBAA include:
Kuo et al (2016) MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery. Am J Physiol Heart Circ Physiol 310 H71 PMID: 26519030
Bianca et al (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Nat Commun 161 1835 PMID: 20825409
Do you know of a great paper that uses OBAA from Tocris? Please let us know.
Reviews for OBAA
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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