A potent inhibitor of phospholipase A2 (IC50 = 70 nM). Reduces bronchospasm in guinea pigs in vivo.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||4.29||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 428.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.33 mL||11.66 mL||23.33 mL|
|5 mM||0.47 mL||2.33 mL||4.67 mL|
|10 mM||0.23 mL||1.17 mL||2.33 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References are publications that support the products' biological activity.
Kohler et al (1991) Phospholipase-A2 inhibition by alkylbenzoyl acrylic acids. Agents Actions 32 70 PMID: 2058477
Kohler et al (1992) Phospholipase A2 inhibition by alkylbenzoyl acrylic acids. Biochem.Pharmacol. 44 805 PMID: 1324685
Madi et al (1991) Allergen-induced bronchospasm in passively sensitized guinea-pigs - influence of new substances in comparison to reference compounds. Agents Actions 32 144 PMID: 2058463
If you know of a relevant reference for OBAA, please let us know.
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Keywords: OBAA, supplier, Phospholipases, A2, inhibitors, inhibits, PLA, sPLA2, Esterases, Phospholipases, Phospholipases, Tocris Bioscience
1 Citation for OBAA
Citations are publications that use Tocris products. Selected citations for OBAA include:
Bianca et al (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Nat Commun 161 1835 PMID: 20825409
Do you know of a great paper that uses OBAA from Tocris? If so please let us know.
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