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Cat.No. 0606 - OBAA | C28H44O3 | CAS No. 221632-26-4
Description: Phospholipase A2 inhibitor
Chemical Name: 4-(4-Octadecylphenyl)-4-oxobutenoic acid
Citations (2)
Reviews (1)
Literature (3)

Biological Activity for OBAA

OBAA is a potent inhibitor of phospholipase A2 (IC50 = 70 nM). Reduces bronchospasm in guinea pigs in vivo.

Technical Data for OBAA

M. Wt 428.65
Formula C28H44O3
Storage Desiccate at +4°C
CAS Number 221632-26-4
PubChem ID 5353842

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OBAA

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.29 10 with gentle warming

Preparing Stock Solutions for OBAA

The following data is based on the product molecular weight 428.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.33 mL 116.65 mL 233.29 mL
0.5 mM 4.67 mL 23.33 mL 46.66 mL
1 mM 2.33 mL 11.66 mL 23.33 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

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References for OBAA

References are publications that support the biological activity of the product.

Kohler et al (1991) Phospholipase-A2 inhibition by alkylbenzoyl acrylic acids. Agents Actions 32 70 PMID: 2058477

Kohler et al (1992) Phospholipase A2 inhibition by alkylbenzoyl acrylic acids. Biochem.Pharmacol. 44 805 PMID: 1324685

Madi et al (1991) Allergen-induced bronchospasm in passively sensitized guinea-pigs - influence of new substances in comparison to reference compounds. Agents Actions 32 144 PMID: 2058463

If you know of a relevant reference for OBAA, please let us know.

View Related Products by Target

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Keywords: OBAA, OBAA supplier, Phospholipases, A2, inhibitors, inhibits, PLA, sPLA2, Esterases, 0606, Tocris Bioscience

2 Citations for OBAA

Citations are publications that use Tocris products. Selected citations for OBAA include:

Kuo et al (2016) MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery. Am J Physiol Heart Circ Physiol 310 H71 PMID: 26519030

Bianca et al (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Nat Commun 161 1835 PMID: 20825409

Do you know of a great paper that uses OBAA from Tocris? Please let us know.

Reviews for OBAA

Average Rating: 5 (Based on 1 Review.)

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used this drug as an inhibitor.
By Anonymous on 10/05/2017
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: macrophages

Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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