OB-1

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Cat.No. 6545 - OB-1 | C21H17N3O6 | CAS No. 300803-69-4
Description: Stomatin-like protein-3 (STOML3) oligomerization inhibitor
Chemical Name: Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Stomatin-like protein-3 (STOML3) oligomerization inhibitor. Reduces STOML3 cluster size in the plasma membrane. Decreases mechanically-induced Piezo1 but not ASIC3 current amplitudes in N2a cells and cultured mouse sensory neurons in vitro. Subcutaneous administration in mice reversibly silences touch receptor activity and inhibits paw withdrawal reflex in a mouse neuropathic pain model.

Technical Data

M. Wt 407.38
Formula C21H17N3O6
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 300803-69-4
Smiles CCOC(C1=C(C2=CC=CC=C2)OC3=CC=C(C=C13)OC4=C([N+]([O-])=O)N=CN4C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.37 50

Preparing Stock Solutions

The following data is based on the product molecular weight 407.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.91 mL 24.55 mL 49.09 mL
2.5 mM 0.98 mL 4.91 mL 9.82 mL
5 mM 0.49 mL 2.45 mL 4.91 mL
25 mM 0.1 mL 0.49 mL 0.98 mL

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References

References are publications that support the biological activity of the product.

Wetzel et al (2017) Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nat.Neurosci. 20 209 PMID: 27941788


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Keywords: OB-1, OB-1 supplier, OB1, Stomatin-like, protein-3, oligomerization, inhibitors, inhibits, mechanosensitive, allodynia, neuropathic, pain, Piezo1, STOML3, Piezo, Channels, 6545, Tocris Bioscience

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