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Biological Activity for OB-1
OB-1 is a stomatin-like protein-3 (STOML3) oligomerization inhibitor. Reduces STOML3 cluster size in the plasma membrane. Decreases mechanically-induced Piezo1 but not ASIC3 current amplitudes in N2a cells and cultured mouse sensory neurons in vitro. Subcutaneous administration in mice reversibly silences touch receptor activity and inhibits paw withdrawal reflex in a mouse neuropathic pain model.
Compound Libraries for OB-1
Technical Data for OB-1
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for OB-1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for OB-1
The following data is based on the product molecular weight 407.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.91 mL||24.55 mL||49.09 mL|
|2.5 mM||0.98 mL||4.91 mL||9.82 mL|
|5 mM||0.49 mL||2.45 mL||4.91 mL|
|25 mM||0.1 mL||0.49 mL||0.98 mL|
References for OB-1
References are publications that support the biological activity of the product.
Wetzel et al (2017) Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nat.Neurosci. 20 209 PMID: 27941788
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Keywords: OB-1, OB-1 supplier, OB1, Stomatin-like, protein-3, oligomerization, inhibitors, inhibits, mechanosensitive, allodynia, neuropathic, pain, Piezo1, STOML3, Piezo, Channels, 6545, Tocris Bioscience
Citations for OB-1
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