Pricing Availability   Qty
Description: Stomatin-like protein-3 (STOML3) oligomerization inhibitor
Chemical Name: Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate
Purity: ≥98% (HPLC)

Biological Activity for OB-1

OB-1 is a stomatin-like protein-3 (STOML3) oligomerization inhibitor. Reduces STOML3 cluster size in the plasma membrane. Decreases mechanically-induced Piezo1 but not ASIC3 current amplitudes in N2a cells and cultured mouse sensory neurons in vitro. Subcutaneous administration in mice reversibly silences touch receptor activity and inhibits paw withdrawal reflex in a mouse neuropathic pain model.

Compound Libraries for OB-1

OB-1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for OB-1

M. Wt 407.38
Formula C21H17N3O6
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 300803-69-4
PubChem ID 1113704
Smiles CCOC(C1=C(C2=CC=CC=C2)OC3=CC=C(C=C13)OC4=C([N+]([O-])=O)N=CN4C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OB-1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.37 50

Preparing Stock Solutions for OB-1

The following data is based on the product molecular weight 407.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.91 mL 24.55 mL 49.09 mL
2.5 mM 0.98 mL 4.91 mL 9.82 mL
5 mM 0.49 mL 2.45 mL 4.91 mL
25 mM 0.1 mL 0.49 mL 0.98 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for OB-1

References are publications that support the biological activity of the product.

Wetzel et al (2017) Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nat.Neurosci. 20 209 PMID: 27941788

If you know of a relevant reference for OB-1, please let us know.

View Related Products by Target

Keywords: OB-1, OB-1 supplier, OB1, Stomatin-like, protein-3, oligomerization, inhibitors, inhibits, mechanosensitive, allodynia, neuropathic, pain, Piezo1, STOML3, Piezo, Channels, 6545, Tocris Bioscience

Citations for OB-1

Citations are publications that use Tocris products.

Currently there are no citations for OB-1. Do you know of a great paper that uses OB-1 from Tocris? Please let us know.

Reviews for OB-1

There are currently no reviews for this product. Be the first to review OB-1 and earn rewards!

Have you used OB-1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review