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O-1918

Cat. No. 2288 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Silent antagonist for putative abnormal-CBD (Cat. No. 1297) receptor
Chemical Name: 1,3-Dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]benzene
Purity: ≥97% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for O-1918

O-1918 is a selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. Inhibits vasodilation and cell migration induced by abnormal-cannabidiol (abn-CBD; Cat. No. 1297).

Licensing Information

Sold under license from the NIH, US patent 60/312,674

Technical Data for O-1918

M. Wt 286.41
Formula C19H26O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 536697-79-7
PubChem ID 40469923
InChI Key ICHJMVMWPKLUKT-JKSUJKDBSA-N
Smiles COC1=CC(C)=CC(OC)=C1[C@@H]1C=C(C)CC[C@H]1C(C)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for O-1918

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.64 100
ethanol 28.64 100

Preparing Stock Solutions for O-1918

The following data is based on the product molecular weight 286.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.46 mL 34.91 mL
5 mM 0.7 mL 3.49 mL 6.98 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References for O-1918

References are publications that support the biological activity of the product.

Offertáler et al (2003) Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol.Pharmacol. 63 699 PMID: 12606780

Mo et al (2004) Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go coupled receptor distinct from CB1, CB2 or EDG-1. Eur.J.Pharmacol. 489 21 PMID: 15063151

Hoi and Hiley (2006) Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. Br.J.Pharmacol. 147 560 PMID: 16415907

If you know of a relevant reference for O-1918, please let us know.

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Keywords: O-1918, O-1918 supplier, Silent, antagonists, putative, abnormal-CBD, receptor, cannabinoids, Receptors, 0-1918, Other, Cannabinoids, 2288, Tocris Bioscience

3 Citations for O-1918

Citations are publications that use Tocris products. Selected citations for O-1918 include:

Herradón et al (2007) Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta. Br J Pharmacol 152 699 PMID: 17704831

Krohn et al (2016) Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment. J Inflamm (Lond) 13 21 PMID: 27418880

Schwartz et al (2018) Up-regulation of heme oxygenase-1 expression and inhibition of disease-associated features by cannabidiol in vascular smooth muscle cells. Oncotarget 9 34595 PMID: 30349652

Do you know of a great paper that uses O-1918 from Tocris? Please let us know.

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Literature in this Area

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