Pricing Availability   Qty
Description: Silent antagonist for putative abnormal-CBD (Cat. No. 1297) receptor
Chemical Name: 1,3-Dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]benzene
Purity: ≥97% (HPLC)
Citations (3)
Literature (2)

Biological Activity for O-1918

O-1918 is a selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. Inhibits vasodilation and cell migration induced by abnormal-cannabidiol (abn-CBD; Cat. No. 1297).

Licensing Information

Sold under license from the NIH, US patent 60/312,674

Technical Data for O-1918

M. Wt 286.41
Formula C19H26O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 536697-79-7
PubChem ID 40469923
Smiles COC1=CC(C)=CC(OC)=C1[C@@H]1C=C(C)CC[C@H]1C(C)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for O-1918

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.64 100
ethanol 28.64 100

Preparing Stock Solutions for O-1918

The following data is based on the product molecular weight 286.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.46 mL 34.91 mL
5 mM 0.7 mL 3.49 mL 6.98 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for O-1918

References are publications that support the biological activity of the product.

Offertáler et al (2003) Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol.Pharmacol. 63 699 PMID: 12606780

Mo et al (2004) Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go coupled receptor distinct from CB1, CB2 or EDG-1. Eur.J.Pharmacol. 489 21 PMID: 15063151

Hoi and Hiley (2006) Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. Br.J.Pharmacol. 147 560 PMID: 16415907

If you know of a relevant reference for O-1918, please let us know.

View Related Products by Target

Keywords: O-1918, O-1918 supplier, Silent, antagonists, putative, abnormal-CBD, receptor, cannabinoids, Receptors, 0-1918, Other, Cannabinoids, 2288, Tocris Bioscience

3 Citations for O-1918

Citations are publications that use Tocris products. Selected citations for O-1918 include:

Herradón et al (2007) Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta. Br J Pharmacol 152 699 PMID: 17704831

Krohn et al (2016) Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment. J Inflamm (Lond) 13 21 PMID: 27418880

Schwartz et al (2018) Up-regulation of heme oxygenase-1 expression and inhibition of disease-associated features by cannabidiol in vascular smooth muscle cells. Oncotarget 9 34595 PMID: 30349652

Do you know of a great paper that uses O-1918 from Tocris? Please let us know.

Reviews for O-1918

There are currently no reviews for this product. Be the first to review O-1918 and earn rewards!

Have you used O-1918?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.