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Cat.No. 2288 - O-1918 | C19H26O2 | CAS No. 536697-79-7
Description: Silent antagonist for putative abnormal-CBD (Cat. No. 1297) receptor
Chemical Name: 1,3-Dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]benzene
Purity: ≥97% (HPLC)

Biological Activity

Selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. Inhibits vasodilation and cell migration induced by abnormal-cannabidiol (abn-CBD; Cat. No. 1297).

Licensing Information

Sold under license from the NIH, US patent 60/312,674

Compound Libraries

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Technical Data

M. Wt 286.41
Formula C19H26O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 536697-79-7
PubChem ID 40469923
Smiles COC1=CC(C)=CC(OC)=C1[C@@H]1C=C(C)CC[C@H]1C(C)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.64 100
ethanol 28.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 286.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.46 mL 34.91 mL
5 mM 0.7 mL 3.49 mL 6.98 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Offertáler et al (2003) Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol.Pharmacol. 63 699 PMID: 12606780

Mo et al (2004) Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go coupled receptor distinct from CB1, CB2 or EDG-1. Eur.J.Pharmacol. 489 21 PMID: 15063151

Hoi and Hiley (2006) Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. Br.J.Pharmacol. 147 560 PMID: 16415907

If you know of a relevant reference for O-1918, please let us know.

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Keywords: O-1918, supplier, Silent, antagonists, putative, abnormal-CBD, receptor, cannabinoids, Receptors, 0-1918, Other, Cannabinoids, Other, Cannabinoids, Tocris Bioscience

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