Neurobehaviorally inactive cannabinoid that acts as a selective agonist for GPR55 (EC50 values are 2.5, >30 and >30 μM at GPR55, CB1 and CB2 receptors respectively). Increases phosphorylation of protein kinases in, and migration of, human umbilical vein endothelial cells.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml)|
Preparing Stock Solutions
The following data is based on the product molecular weight 314.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.18 mL||15.9 mL||31.8 mL|
|5 mM||0.64 mL||3.18 mL||6.36 mL|
|10 mM||0.32 mL||1.59 mL||3.18 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References are publications that support the products' biological activity.
Ho and Hiley (2003) Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery. Br.J.Pharmacol. 138 1320 PMID: 12711633
Jarai et al (1999) Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc.Natl.Acad.Sci.U.S.A. 96 14136 PMID: 10570211
Mo et al (2004) Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. Eur.J.Pharmacol. 489 21 PMID: 15063151
Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302
If you know of a relevant reference for Abn-CBD, please let us know.
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Keywords: Abn-CBD, supplier, Selective, GPR55, agonists, neurobehaviorally, inactive, Cannabinoids, Receptors, Abnormal-cannabidiol, GPR55, GPR55, Tocris Bioscience
3 Citations for Abn-CBD
Citations are publications that use Tocris products. Selected citations for Abn-CBD include:
Hao et al (2015) Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis. Cell Death Dis 21 38 PMID: 25569804
Yang et al (2014) Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free Radic Biol Med 68 260 PMID: 24398069
Esposito et al (2007) Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol 151 1272 PMID: 17592514
Do you know of a great paper that uses Abn-CBD from Tocris? If so please let us know.
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