Discontinued Product

NVP CXCR2 20 (Cat. No. 5660) has been withdrawn from sale for commercial reasons.
Description: Potent and selective CXCR2 antagonist
Chemical Name: 4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for NVP CXCR2 20

Potent and selective CXCR2 antagonist (IC50 = 40 nM). Exhibits selectivity for CXCR2 over a panel of 49 other GPCRs. Orally bioavailable.

Compound Libraries for NVP CXCR2 20

NVP CXCR2 20 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for NVP CXCR2 20

M. Wt 319.33
Formula C15H11F2N3OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1029521-30-9
PubChem ID 24955240
Smiles OC1=C(C#N)C(C2CC2)=NC(SCC3=CC=CC(F)=C3F)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for NVP CXCR2 20

References are publications that support the biological activity of the product.

Porter et al (2014) The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists. Bioorg.Med.Chem.Lett. 24 3285 PMID: 24974342

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Keywords: NVP CXCR2 20, NVP CXCR2 20 supplier, NVPCXCR220, chemokine, cxc, receptors, antagonists, antagonism, orally, bioavailable, potent, selective, Chemokine, CXC, Receptors, 5660, Tocris Bioscience

Citations for NVP CXCR2 20

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Currently there are no citations for NVP CXCR2 20.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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