NVP CXCR2 20

Pricing Availability Delivery Time Qty
Cat.No. 5660 - NVP CXCR2 20 | C15H11F2N3OS | CAS No. 1029521-30-9
Description: Potent and selective CXCR2 antagonist
Chemical Name: 4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective CXCR2 antagonist (IC50 = 40 nM). Exhibits selectivity for CXCR2 over a panel of 49 other GPCRs. Orally bioavailable.

Technical Data

M. Wt 319.33
Formula C15H11F2N3OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1029521-30-9
PubChem ID 24955240
InChI Key PHHZYKZFEBRXAL-UHFFFAOYSA-N
Smiles OC1=C(C#N)C(C2CC2)=NC(SCC3=CC=CC(F)=C3F)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 3.19 10mM with sonication
DMSO 15.97 50

Preparing Stock Solutions

The following data is based on the product molecular weight 319.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.32 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Porter et al (2014) The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists. Bioorg.Med.Chem.Lett. 24 3285 PMID: 24974342


If you know of a relevant reference for NVP CXCR2 20, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Chemokine CXC Receptor Antagonists

Keywords: NVPCXCR220 chemokine cxc receptors antagonists antagonism orally bioavailable potent selective Chemokine CXC Receptors

Citations for NVP CXCR2 20

Citations are publications that use Tocris products.

Currently there are no citations for NVP CXCR2 20. Do you know of a great paper that uses NVP CXCR2 20 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for NVP CXCR2 20

Protocols

TODO: Add Protocols