NVP CXCR2 20

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Cat.No. 5660 - NVP CXCR2 20 | C15H11F2N3OS | CAS No. 1029521-30-9
Description: Potent and selective CXCR2 antagonist
Chemical Name: 4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective CXCR2 antagonist (IC50 = 40 nM). Exhibits selectivity for CXCR2 over a panel of 49 other GPCRs. Orally bioavailable.

Technical Data

M. Wt 319.33
Formula C15H11F2N3OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1029521-30-9
PubChem ID 24955240
InChI Key PHHZYKZFEBRXAL-UHFFFAOYSA-N
Smiles OC1=C(C#N)C(C2CC2)=NC(SCC3=CC=CC(F)=C3F)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.97 50

Preparing Stock Solutions

The following data is based on the product molecular weight 319.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.32 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Porter et al (2014) The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists. Bioorg.Med.Chem.Lett. 24 3285 PMID: 24974342


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Citations for NVP CXCR2 20

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