NU 6140

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Description: Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B
Chemical Name: 4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide
Purity: ≥99% (HPLC)
Citations (4)

Biological Activity for NU 6140

NU 6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor (IC50 values are 0.42 - 1.1 μM). Displays some selectivity for cdk2 (IC50 value = 0.94 μM for cdk4 and >2.3 μM for other cdks). Induces cell-cycle arrest at the G2-M phase. Potentiates the apoptotic effect of taxol (Cat. No. 1097) in HeLa cells; down-regulates the antiapoptotic protein survivin. Also potently inhibits aurora kinases (IC50 values are 0.035 and 0.067 μM for aurora kinase B and A, respectively).

Compound Libraries for NU 6140

NU 6140 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NU 6140

M. Wt 422.52
Formula C23H30N6O2
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 444723-13-1
PubChem ID 10202471
Smiles O=C(N(CC)CC)C(C=C4)=CC=C4NC1=NC(NC=N2)=C2C(OCC3CCCCC3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NU 6140

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.25 100
ethanol 42.25 100

Preparing Stock Solutions for NU 6140

The following data is based on the product molecular weight 422.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.83 mL 23.67 mL
5 mM 0.47 mL 2.37 mL 4.73 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References for NU 6140

References are publications that support the biological activity of the product.

Pennati et al (2005) Potentiation of PacT.-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol.Cancer.Ther. 4 1328 PMID: 16170024

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for NU 6140, please let us know.

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Keywords: NU 6140, NU 6140 supplier, NU6140, cdk2, inhibitor, cyclin-dependent, kinase, inhibitors, inhibits, anti-apoptotic, arrests, cell, cycle, Cyclin-dependent, Kinase, Aurora, Kinases, CDK1, Subfamily, 3301, Tocris Bioscience

4 Citations for NU 6140

Citations are publications that use Tocris products. Selected citations for NU 6140 include:

Berenjeno et al (2017) Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling. Nat Commun 8 1773 PMID: 29170395

Musa et al (2019) Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes. Nat Commun 10 4128 PMID: 31511524

Boekhout et al (2016) Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression. EMBO Rep 17 414 PMID: 26882548

Zhang et al (2016) miR-200b induces cell cycle arrest and represses cell growth in esophageal squamous cell carcinoma. Carcinogenesis 37 858 PMID: 27496804

Do you know of a great paper that uses NU 6140 from Tocris? Please let us know.

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