NTR 368

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Cat.No. 2087 - NTR 368 | Ac-Ala-Thr-Leu-Asp-Ala-Leu-Leu-Ala-Ala-Leu-Arg-Arg-Ile-Gln-NH2 | CAS No. 197230-90-3
Description: p75NTR fragment; induces apoptosis
Alternative Names: Neurotrophin receptor (368-381) amide
Datasheet
Citations

Biological Activity

Peptide fragment corresponding to residues 368-381 of the human p75 neurotrophin receptor (p75NTR). Forms a helical structure in the presence of micellar lipid. Induces apoptosis in human neuroblastoma cells in vitro.

Technical Data

M. Wt 1565.87
Formula C69H124N22O19
Sequence ATLDALLAALRRIQ-amide

(Modifications: Ala-1 = N-terminal Ac, Gln-14 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 197230-90-3
PubChem ID 90488737
InChI Key ZUALDXYFESKMAR-SMVIZIMZSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1565.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.64 mL 3.19 mL 6.39 mL
5 mM 0.13 mL 0.64 mL 1.28 mL
10 mM 0.06 mL 0.32 mL 0.64 mL
50 mM 0.01 mL 0.06 mL 0.13 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hileman et al (1997) A cytoplasmic peptide of the neurotrophin receptor p75NTR: induction of apoptosis and NMR determined helical conformation. FEBS Lett. 415 145 PMID: 9350985


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View Related Products by Target

Keywords: p75NTR fragment induces apoptosis Neurotrophin Receptors p75 Trk RTKs Receptor Tyrosine Kinases NTR368 Neurotrophin receptor (368-381) amide Trk Receptors

Citations for NTR 368

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