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Biological Activity for NTNCB hydrochloride
NTNCB hydrochloride is a selective, non-peptide competitive NPY Y5 antagonist. Ki values are 8.0 and 16032 nM at human recombinant Y5 and Y1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Displays some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively).
Technical Data for NTNCB hydrochloride
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NTNCB hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NTNCB hydrochloride
The following data is based on the product molecular weight 508.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.97 mL||9.84 mL||19.68 mL|
|5 mM||0.39 mL||1.97 mL||3.94 mL|
|10 mM||0.2 mL||0.98 mL||1.97 mL|
|50 mM||0.04 mL||0.2 mL||0.39 mL|
Product Datasheets for NTNCB hydrochloride
References for NTNCB hydrochloride
References are publications that support the biological activity of the product.
Islam et al (2002) Discovery of potent and selective small molecule NPY Y5 receptor antagonists. Bioorg.Med.Chem.Lett. 12 1767 PMID: 12067557
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Keywords: NTNCB hydrochloride, NTNCB hydrochloride supplier, Potent, selective, non-peptidic, Y5, antagonists, Neuropeptide, Y, Receptors, NPY, neuropeptides, 2155, Tocris Bioscience
Citations for NTNCB hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.