Selective, non-peptide competitive NPY Y5 antagonist. Ki values are 8.0 and 16032 nM at human recombinant Y5 and Y1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Displays some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 508.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.97 mL||9.84 mL||19.68 mL|
|5 mM||0.39 mL||1.97 mL||3.94 mL|
|10 mM||0.2 mL||0.98 mL||1.97 mL|
|50 mM||0.04 mL||0.2 mL||0.39 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Islam et al (2002) Discovery of potent and selective small molecule NPY Y5 receptor antagonists. Bioorg.Med.Chem.Lett. 12 1767 PMID: 12067557
If you know of a relevant reference for NTNCB hydrochloride, please let us know.
View Related Products by Product Action
Keywords: NTNCB hydrochloride, supplier, Potent, selective, non-peptidic, Y5, antagonists, Neuropeptide, Y, Receptors, NPY, neuropeptides, NPY, Receptors, Tocris Bioscience
Citations for NTNCB hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for NTNCB hydrochloride. Do you know of a great paper that uses NTNCB hydrochloride from Tocris? If so please let us know.
Literature in this Area
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.