NTNCB hydrochloride

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Cat.No. 2155 - NTNCB hydrochloride | C25H33N3O4S.HCl | CAS No. 191931-56-3
Description: Potent and selective non-peptidic NPY Y5 antagonist
Chemical Name: 2-Nitro-N-[[trans-4-[[[(1,2,3,4-tetrahydro-2-naphthalenyl)methyl]amino]methyl]cyclohexyl]methyl]benzenesulfonamide hydrochloride
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for NTNCB hydrochloride

NTNCB hydrochloride is a selective, non-peptide competitive NPY Y5 antagonist. Ki values are 8.0 and 16032 nM at human recombinant Y5 and Y1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Displays some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively).

Technical Data for NTNCB hydrochloride

M. Wt 508.07
Formula C25H33N3O4S.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 191931-56-3
PubChem ID 124081021
Smiles O=S(NC[C@@H](CC3)CC[C@H]3CNCC2CCC1=CC=CC=C1C2)(C4=C([N+]([O-])=O)C=CC=C4)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NTNCB hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 50.81 100

Preparing Stock Solutions for NTNCB hydrochloride

The following data is based on the product molecular weight 508.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.84 mL 19.68 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.98 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets for NTNCB hydrochloride

Certificate of Analysis / Product Datasheet
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References for NTNCB hydrochloride

References are publications that support the biological activity of the product.

Islam et al (2002) Discovery of potent and selective small molecule NPY Y5 receptor antagonists. Bioorg.Med.Chem.Lett. 12 1767 PMID: 12067557

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