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Description: KDM4A/KDM4B inhibitor
Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
Purity: ≥98% (HPLC)
Biological Activity for NSC 636819
NSC 636819 is a KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.
Technical Data for NSC 636819
| M. Wt | 510.15 |
| Formula | C22H12Cl4N2O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1618672-71-1 |
| PubChem ID | 6288112 |
| InChI Key | YYZPXBXVBQSBDG-IJIVKGSJSA-N |
| Smiles | ClC(C=C1)=C(Cl)C=C1/C=C/C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(/C=C/C3=CC=C(Cl)C(Cl)=C3)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NSC 636819
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.1 | 10 |
Preparing Stock Solutions for NSC 636819
The following data is based on the product molecular weight 510.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.6 mL | 98.01 mL | 196.02 mL |
| 0.5 mM | 3.92 mL | 19.6 mL | 39.2 mL |
| 1 mM | 1.96 mL | 9.8 mL | 19.6 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.92 mL |
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Product Datasheets for NSC 636819
References for NSC 636819
References are publications that support the biological activity of the product.
Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975 PMID: 24971742
If you know of a relevant reference for NSC 636819, please let us know.
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Keywords: NSC 636819, NSC 636819 supplier, NSC636819, KDM4A, KDM4B, inhibitors, inhibits, prostate, cancer, androgen-responsive, histones, demethylases, Histone, Demethylases, 5287, Tocris Bioscience
Citations for NSC 636819
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Literature in this Area
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