NSC 636819
Biological Activity
KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.
Technical Data
| M. Wt | 510.15 |
| Formula | C22H12Cl4N2O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1618672-71-1 |
| PubChem ID | 6288112 |
| InChI Key | YYZPXBXVBQSBDG-IJIVKGSJSA-N |
| Smiles | ClC(C=C1)=C(Cl)C=C1/C=C/C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(/C=C/C3=CC=C(Cl)C(Cl)=C3)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.1 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 510.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.6 mL | 98.01 mL | 196.02 mL |
| 0.5 mM | 3.92 mL | 19.6 mL | 39.2 mL |
| 1 mM | 1.96 mL | 9.8 mL | 19.6 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.92 mL |
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References
References are publications that support the biological activity of the product.
Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975 PMID: 24971742
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Keywords: NSC 636819, NSC 636819 supplier, NSC636819, KDM4A, KDM4B, inhibitors, inhibits, prostate, cancer, androgen-responsive, histones, demethylases, Histone, Demethylases, 5287, Tocris Bioscience
Citations for NSC 636819
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Reviews for NSC 636819
Average Rating: 5 (Based on 1 Review.)
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Used for inhibiting H3K9me3 demethylases on Pancreatic Cancer cell lines. works pretty well.
Literature in this Area
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- Bromodomains
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases
