NSC 636819

Pricing Availability Delivery Time Qty
Cat.No. 5287 - NSC 636819 | C22H12Cl4N2O4 | CAS No. 1618672-71-1
Description: KDM4A/KDM4B inhibitor
Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.

Technical Data

M. Wt 510.15
Formula C22H12Cl4N2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1618672-71-1
PubChem ID 6288112
InChI Key YYZPXBXVBQSBDG-IJIVKGSJSA-N
Smiles ClC(C=C1)=C(Cl)C=C1/C=C/C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(/C=C/C3=CC=C(Cl)C(Cl)=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.1 10

Preparing Stock Solutions

The following data is based on the product molecular weight 510.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.8 mL 19.6 mL
5 mM 0.39 mL 1.96 mL 3.92 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975 PMID: 24971742


If you know of a relevant reference for NSC 636819, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Histone Demethylase Inhibitors

Keywords: NSC 636819, supplier, NSC636819, KDM4A, KDM4B, inhibitors, inhibits, prostate, cancer, androgen-responsive, histones, demethylases, Histone, Demethylases, Tocris Bioscience

Citations for NSC 636819

Citations are publications that use Tocris products.

Currently there are no citations for NSC 636819. Do you know of a great paper that uses NSC 636819 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases

Pathways for NSC 636819

Protocols

TODO: Add Protocols