Home / Pharmacology / Enzymes / Demethylases / Histone Demethylases / Histone Demethylase Inhibitors / NSC 636819

NSC 636819

Cat. No. 5287 Submit a Review Datasheet / COA / SDS
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Description: KDM4A/KDM4B inhibitor
Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NSC 636819

NSC 636819 is a KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.

Technical Data for NSC 636819

M. Wt 510.15
Formula C22H12Cl4N2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1618672-71-1
PubChem ID 6288112
InChI Key YYZPXBXVBQSBDG-IJIVKGSJSA-N
Smiles ClC(C=C1)=C(Cl)C=C1/C=C/C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(/C=C/C3=CC=C(Cl)C(Cl)=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NSC 636819

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.1 10

Preparing Stock Solutions for NSC 636819

The following data is based on the product molecular weight 510.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.6 mL 98.01 mL 196.02 mL
0.5 mM 3.92 mL 19.6 mL 39.2 mL
1 mM 1.96 mL 9.8 mL 19.6 mL
5 mM 0.39 mL 1.96 mL 3.92 mL

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References for NSC 636819

References are publications that support the biological activity of the product.

Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975 PMID: 24971742

If you know of a relevant reference for NSC 636819, please let us know.

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Keywords: NSC 636819, NSC 636819 supplier, NSC636819, KDM4A, KDM4B, inhibitors, inhibits, prostate, cancer, androgen-responsive, histones, demethylases, Histone, Demethylases, 5287, Tocris Bioscience

Citations for NSC 636819

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