NSC 636819

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: KDM4A/KDM4B inhibitor
Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for NSC 636819

NSC 636819 is a KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.

Technical Data for NSC 636819

M. Wt 510.15
Formula C22H12Cl4N2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1618672-71-1
PubChem ID 6288112
Smiles ClC(C=C1)=C(Cl)C=C1/C=C/C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(/C=C/C3=CC=C(Cl)C(Cl)=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NSC 636819

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.1 10

Preparing Stock Solutions for NSC 636819

The following data is based on the product molecular weight 510.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.6 mL 98.01 mL 196.02 mL
0.5 mM 3.92 mL 19.6 mL 39.2 mL
1 mM 1.96 mL 9.8 mL 19.6 mL
5 mM 0.39 mL 1.96 mL 3.92 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for NSC 636819

References are publications that support the biological activity of the product.

Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975 PMID: 24971742

If you know of a relevant reference for NSC 636819, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Histone Demethylase Inhibitors

Keywords: NSC 636819, NSC 636819 supplier, NSC636819, KDM4A, KDM4B, inhibitors, inhibits, prostate, cancer, androgen-responsive, histones, demethylases, Histone, Demethylases, 5287, Tocris Bioscience

Citations for NSC 636819

Citations are publications that use Tocris products.

Currently there are no citations for NSC 636819. Do you know of a great paper that uses NSC 636819 from Tocris? Please let us know.

Reviews for NSC 636819

There are currently no reviews for this product. Be the first to review NSC 636819 and earn rewards!

Have you used NSC 636819?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.