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NSC 632839 hydrochloride
Biological Activity for NSC 632839 hydrochloride
NSC 632839 hydrochloride is an inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).
Technical Data for NSC 632839 hydrochloride
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NSC 632839 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NSC 632839 hydrochloride
The following data is based on the product molecular weight 339.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||11.77 mL||58.85 mL||117.7 mL|
|1.25 mM||2.35 mL||11.77 mL||23.54 mL|
|2.5 mM||1.18 mL||5.88 mL||11.77 mL|
|12.5 mM||0.24 mL||1.18 mL||2.35 mL|
Product Datasheets for NSC 632839 hydrochloride
References for NSC 632839 hydrochloride
References are publications that support the biological activity of the product.
Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235 PMID: 16982768
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2 Citations for NSC 632839 hydrochloride
Citations are publications that use Tocris products. Selected citations for NSC 632839 hydrochloride include:
Ryals et al (2018) The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity. Front Cell Neurosci 12 445 PMID: 30532693
Zeng et al (2016) CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature 7 11364 PMID: 27098497
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Reviews for NSC 632839 hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound