NSC 632839 hydrochloride

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Cat.No. 2647 - NSC 632839 hydrochloride | C21H21NO.HCl | CAS No. 157654-67-6
Description: Inhibitor of ubiquitin isopeptidase activity
Alternative Names: F6
Chemical Name: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).

Compound Libraries

NSC 632839 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 339.86
Formula C21H21NO.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 157654-67-6
PubChem ID 5351362
InChI Key ZOKZLTXPTLIWOJ-BYCVLTJGSA-N
Smiles O=C(/C(CNC3)=C/C2=CC=C(C)C=C2)/C3=C/C1=CC=C(C)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.49 25

Preparing Stock Solutions

The following data is based on the product molecular weight 339.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.71 mL 29.42 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235 PMID: 16982768


If you know of a relevant reference for NSC 632839 hydrochloride, please let us know.

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View all Deubiquitinating Enzyme Inhibitors

Keywords: inhibitors inhibits ubiquitin isopeptidase activity Proteases Proteinases NSC632839 hydrochloride F6 Deubiquitinating Enzymes

1 Citation for NSC 632839 hydrochloride

Citations are publications that use Tocris products. Selected citations for NSC 632839 hydrochloride include:

Zeng et al (2016) CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature 7 11364 PMID: 27098497


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New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for NSC 632839 hydrochloride

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