NSC 632839 hydrochloride
Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 339.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.94 mL||14.71 mL||29.42 mL|
|5 mM||0.59 mL||2.94 mL||5.88 mL|
|10 mM||0.29 mL||1.47 mL||2.94 mL|
|50 mM||0.06 mL||0.29 mL||0.59 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235 PMID: 16982768
If you know of a relevant reference for NSC 632839 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: inhibitors inhibits ubiquitin isopeptidase activity Proteases Proteinases NSC632839 hydrochloride F6 Deubiquitinating Enzymes
1 Citation for NSC 632839 hydrochloride
Citations are publications that use Tocris products. Selected citations for NSC 632839 hydrochloride include:
Zeng et al (2016) CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature 7 11364 PMID: 27098497
Do you know of a great paper that uses NSC 632839 hydrochloride from Tocris? If so please let us know.
Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells