NSC 632839 hydrochloride

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Cat.No. 2647 - NSC 632839 hydrochloride | C21H21NO.HCl | CAS No. 157654-67-6
Description: Inhibitor of ubiquitin isopeptidase activity
Alternative Names: F6
Chemical Name: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
Purity: ≥99% (HPLC)
Citations (2)
Reviews (1)

Biological Activity for NSC 632839 hydrochloride

NSC 632839 hydrochloride is an inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).

Technical Data for NSC 632839 hydrochloride

M. Wt 339.86
Formula C21H21NO.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 157654-67-6
PubChem ID 5351362
Smiles O=C(/C(CNC3)=C/C2=CC=C(C)C=C2)/C3=C/C1=CC=C(C)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NSC 632839 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.49 25

Preparing Stock Solutions for NSC 632839 hydrochloride

The following data is based on the product molecular weight 339.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 11.77 mL 58.85 mL 117.7 mL
1.25 mM 2.35 mL 11.77 mL 23.54 mL
2.5 mM 1.18 mL 5.88 mL 11.77 mL
12.5 mM 0.24 mL 1.18 mL 2.35 mL

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Product Datasheets for NSC 632839 hydrochloride

References for NSC 632839 hydrochloride

References are publications that support the biological activity of the product.

Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235 PMID: 16982768

If you know of a relevant reference for NSC 632839 hydrochloride, please let us know.

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2 Citations for NSC 632839 hydrochloride

Citations are publications that use Tocris products. Selected citations for NSC 632839 hydrochloride include:

Ryals et al (2018) The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity. Front Cell Neurosci 12 445 PMID: 30532693

Zeng et al (2016) CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature 7 11364 PMID: 27098497

Do you know of a great paper that uses NSC 632839 hydrochloride from Tocris? Please let us know.

Reviews for NSC 632839 hydrochloride

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42 perturbagens used the zebrafish DASPEI screen.
By Anonymous on 12/17/2019
Assay Type: In Vivo
Species: Other
Cell Line/Tissue: larvae

Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound

PMID: 30532693
review image