NSC 632839 hydrochloride

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Cat.No. 2647 - NSC 632839 hydrochloride | C21H21NO.HCl | CAS No. 157654-67-6
Description: Inhibitor of ubiquitin isopeptidase activity
Alternative Names: F6
Chemical Name: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).

Compound Libraries

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Technical Data

M. Wt 339.86
Formula C21H21NO.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 157654-67-6
PubChem ID 5351362
Smiles O=C(/C(CNC3)=C/C2=CC=C(C)C=C2)/C3=C/C1=CC=C(C)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.49 25

Preparing Stock Solutions

The following data is based on the product molecular weight 339.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 11.77 mL 58.85 mL 117.7 mL
1.25 mM 2.35 mL 11.77 mL 23.54 mL
2.5 mM 1.18 mL 5.88 mL 11.77 mL
12.5 mM 0.24 mL 1.18 mL 2.35 mL

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References are publications that support the biological activity of the product.

Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235 PMID: 16982768

If you know of a relevant reference for NSC 632839 hydrochloride, please let us know.

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1 Citation for NSC 632839 hydrochloride

Citations are publications that use Tocris products. Selected citations for NSC 632839 hydrochloride include:

Zeng et al (2016) CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature 7 11364 PMID: 27098497

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