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NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.
NSC 146109 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285 PMID: 12676586
Berkson et al (2005) Pilot screening programme for small molecule activators of p53. Int.J.Cancer 115 701 PMID: 15729694
Keywords: NSC 146109 hydrochloride, NSC 146109 hydrochloride supplier, Cell-permeable, genotype-selective, antitumor, agent, activates, p53-dependent, transcription, p53, Transcription, Factors, MDM2, p14ARF, NSC146109, hydrochloride, 2185, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for NSC 146109 hydrochloride include:
Calo et al (2018) Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature 554 112 PMID: 29364875
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p53-mediated apoptosis after treatment with NSC146109 for 12–16 hours
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This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.