NSC 146109 hydrochloride

Discontinued Product

NSC 146109 hydrochloride (Cat. No. 2185) has been withdrawn from sale for commercial reasons.
Description: Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
Chemical Name: (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
Purity: ≥97% (HPLC)
Citations (1)
Reviews (1)
Literature (3)
Pathways (1)

Biological Activity for NSC 146109 hydrochloride

NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.

Compound Libraries for NSC 146109 hydrochloride

NSC 146109 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NSC 146109 hydrochloride

M. Wt 316.85
Formula C17H16N2S.HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 59474-01-0
PubChem ID 5458312
Smiles N=C(N)SCC1=C(C=CC=C3)C3=C(C)C2=C1C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for NSC 146109 hydrochloride

References for NSC 146109 hydrochloride

References are publications that support the biological activity of the product.

Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285 PMID: 12676586

Berkson et al (2005) Pilot screening programme for small molecule activators of p53. Int.J.Cancer 115 701 PMID: 15729694

View Related Products by Target

View Related Products by Product Action

View all p53 Activators

Keywords: NSC 146109 hydrochloride, NSC 146109 hydrochloride supplier, Cell-permeable, genotype-selective, antitumor, agent, activates, p53-dependent, transcription, p53, Transcription, Factors, MDM2, p14ARF, NSC146109, hydrochloride, 2185, Tocris Bioscience

1 Citation for NSC 146109 hydrochloride

Citations are publications that use Tocris products. Selected citations for NSC 146109 hydrochloride include:

Calo et al (2018) Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature 554 112 PMID: 29364875

Reviews for NSC 146109 hydrochloride

Average Rating: 4 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used NSC 146109 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

p53 activation.
By Anonymous on 02/29/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: hela

p53-mediated apoptosis after treatment with NSC146109 for 12–16 hours

PMID: 29364875
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for NSC 146109 hydrochloride

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.