NS 6180

Pricing Availability   Qty
Description: Potent KCa3.1 (IK) channel blocker
Chemical Name: 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (2)

Biological Activity for NS 6180

NS 6180 is a potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). Exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Potently inhibits IL-2 and IFN-γ production in rat lymphocytes (IC50 ~ 50 nM); reduces DBNS-induced experimental colitis in rats.

Technical Data for NS 6180

M. Wt 323.33
Formula C16H12F3NOS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 353262-04-1
PubChem ID 11837221
InChI Key ZUIJXKLTUFCDGO-UHFFFAOYSA-N
Smiles O=C2N(CC3=CC=CC(C(F)(F)F)=C3)C1=CC=CC=C1SC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NS 6180

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.33 100
ethanol 32.33 100

Preparing Stock Solutions for NS 6180

The following data is based on the product molecular weight 323.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.09 mL 15.46 mL 30.93 mL
5 mM 0.62 mL 3.09 mL 6.19 mL
10 mM 0.31 mL 1.55 mL 3.09 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for NS 6180

References are publications that support the biological activity of the product.

Strøbæk et al (2013) NS6180, a new KCa3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br.J.Pharmacol. 168 432 PMID: 22891655


If you know of a relevant reference for NS 6180, please let us know.

View Related Products by Product Action

View all Calcium-Activated Potassium (KCa) Channel Blockers

Keywords: NS 6180, NS 6180 supplier, NS6180, KCa3.1, potassium, channels, blockers, inhibitors, inhibits, potent, inflammatory, bowel, disease, gardos, channel, KCNN4, anti-inflammatory, Ca2+-Activated, Potassium, Channels, 4864, Tocris Bioscience

1 Citation for NS 6180

Citations are publications that use Tocris products. Selected citations for NS 6180 include:

Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. Circ Res 173 177 PMID: 26454020


Do you know of a great paper that uses NS 6180 from Tocris? Please let us know.

Reviews for NS 6180

Average Rating: 4 (Based on 1 Review.)

5 Star
0%
4 Star
100%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used NS 6180?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Great product to study KV channel blocking activity.
By Sadequl Islam on 10/13/2018
Assay Type: In Vitro
Species: Mouse

Product is a great K.v channel blocker. Used in studies to understand the mechanism of action of NS 6180 and its differences with other blocker mechanism. The purchased product showed stability and worked well in the study conditions.Would purchase again

Must be dissloved in DMSO

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Ion Channel Product Listing

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Epilepsy Poster

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.