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Submit ReviewNS 6180
Description: Potent KCa3.1 (IK) channel blocker
Chemical Name: 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one
Purity: ≥99% (HPLC)
Biological Activity for NS 6180
NS 6180 is a potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). Exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Potently inhibits IL-2 and IFN-γ production in rat lymphocytes (IC50 ~ 50 nM); reduces DBNS-induced experimental colitis in rats.
Technical Data for NS 6180
| M. Wt | 323.33 |
| Formula | C16H12F3NOS |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 353262-04-1 |
| PubChem ID | 11837221 |
| InChI Key | ZUIJXKLTUFCDGO-UHFFFAOYSA-N |
| Smiles | O=C2N(CC3=CC=CC(C(F)(F)F)=C3)C1=CC=CC=C1SC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NS 6180
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.33 | 100 | |
| ethanol | 32.33 | 100 |
Preparing Stock Solutions for NS 6180
The following data is based on the product molecular weight 323.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.09 mL | 15.46 mL | 30.93 mL |
| 5 mM | 0.62 mL | 3.09 mL | 6.19 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.09 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets for NS 6180
References for NS 6180
References are publications that support the biological activity of the product.
Strøbæk et al (2013) NS6180, a new KCa3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br.J.Pharmacol. 168 432 PMID: 22891655
If you know of a relevant reference for NS 6180, please let us know.
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1 Citation for NS 6180
Citations are publications that use Tocris products. Selected citations for NS 6180 include:
Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. Circ Res 173 177 PMID: 26454020
Do you know of a great paper that uses NS 6180 from Tocris? Please let us know.
Reviews for NS 6180
Average Rating: 4 (Based on 1 Review.)
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Great product to study KV channel blocking activity.
By
Sadequl Islam on 10/13/2018
Assay Type: In Vitro
Species: Mouse
Product is a great K.v channel blocker. Used in studies to understand the mechanism of action of NS 6180 and its differences with other blocker mechanism. The purchased product showed stability and worked well in the study conditions.Would purchase again
Must be dissloved in DMSO
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