NS 6180

Pricing Availability Delivery Time Qty
Cat.No. 4864 - NS 6180 | C16H12F3NOS | CAS No. 353262-04-1
Description: Potent KCa3.1 channel blocker
Chemical Name: 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). Exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Potently inhibits IL-2 and IFN-γ production in rat lymphocytes (IC50 ~ 50 nM); reduces DBNS-induced experimental colitis in rats.

Technical Data

M. Wt 323.33
Formula C16H12F3NOS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 353262-04-1
PubChem ID 11837221
InChI Key ZUIJXKLTUFCDGO-UHFFFAOYSA-N
Smiles O=C2N(CC3=CC=CC(C(F)(F)F)=C3)C1=CC=CC=C1SC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.33 100
ethanol 32.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 323.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.09 mL 15.46 mL 30.93 mL
5 mM 0.62 mL 3.09 mL 6.19 mL
10 mM 0.31 mL 1.55 mL 3.09 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Strøbæk et al (2013) NS6180, a new KCa3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br.J.Pharmacol. 168 432 PMID: 22891655


If you know of a relevant reference for NS 6180, please let us know.

View Related Products by Product Action

View all Calcium-Activated Potassium (KCa) Channel Blockers

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1 Citation for NS 6180

Citations are publications that use Tocris products. Selected citations for NS 6180 include:

Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. Circ Res 173 177 PMID: 26454020


Do you know of a great paper that uses NS 6180 from Tocris? If so please let us know.

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Literature in this Area

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
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  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

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