NS 1619

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Cat.No. 3804 - NS 1619 | C15H8F6N2O2 | CAS No. 153587-01-0
Description: Activator of BKCa (KCa1.1) channels
Chemical Name: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).

Technical Data

M. Wt 362.23
Formula C15H8F6N2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 153587-01-0
PubChem ID 4552
InChI Key YLFMCMWKHSDUCT-UHFFFAOYSA-N
Smiles O=C2NC1=CC(C(F)(F)F)=CC=C1N2C3=CC(C(F)(F)F)=CC=C3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.22 100
ethanol 36.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 362.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.8 mL 27.61 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Olesen et al (1994) Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone. Eur.J.Pharmacol. 251 53 PMID: 8137869

Debska et al (2003) Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem.Pharmacol. 65 1827 PMID: 12781334

Han et al (2008) The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochem.Biophys.Res.Comm. 375 205 PMID:


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View all Calcium-Activated Potassium (KCa) Channel Activators

Keywords: NS1619 Ca2+-activated potassium K+ KCa KCa1.1 channels activators openers large conductance BK maxi-K Ca2+-Activated Potassium Channels

Citations for NS 1619

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