NS 1619

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Cat.No. 3804 - NS 1619 | C15H8F6N2O2 | CAS No. 153587-01-0
Description: Activator of BKCa (KCa1.1) channels
Chemical Name: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (2)
Literature

Biological Activity

Large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).

Technical Data

M. Wt 362.23
Formula C15H8F6N2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 153587-01-0
PubChem ID 4552
InChI Key YLFMCMWKHSDUCT-UHFFFAOYSA-N
Smiles O=C2NC1=CC(C(F)(F)F)=CC=C1N2C3=CC(C(F)(F)F)=CC=C3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.22 100
ethanol 36.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 362.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.8 mL 27.61 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Olesen et al (1994) Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone. Eur.J.Pharmacol. 251 53 PMID: 8137869

Debska et al (2003) Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem.Pharmacol. 65 1827 PMID: 12781334

Han et al (2008) The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochem.Biophys.Res.Comm. 375 205


If you know of a relevant reference for NS 1619, please let us know.

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View all Calcium-Activated Potassium (KCa) Channel Activators

Keywords: NS 1619, NS 1619 supplier, NS1619, Ca2+-activated, potassium, K+, KCa, KCa1.1, channels, activators, openers, large, conductance, BK, maxi-K, Ca2+-Activated, Potassium, Channels, 3804, Tocris Bioscience

Citations for NS 1619

Citations are publications that use Tocris products.

Currently there are no citations for NS 1619. Do you know of a great paper that uses NS 1619 from Tocris? Please let us know.

Reviews for NS 1619

Average Rating: 4.5 (Based on 2 Reviews.)

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BK opening for the treatment of Pulmonary Hypertension
By Mohammad Sadequl on 09/13/2018
Assay Type: In Vitro
Species: Rat

The effect of NS161 as a therapeutic option for pulmonary hypertension was studied in rats. It can be seen from the test results that inhalation of a 12 µM and 100 µM NS1619 solution significantly reduces RV pressure without affecting systemic arterial pressure.

NS1619 inhalation reduces RV pressure and improves oxygen supply and its application inhibits PASMC proliferation in vitro.


Standard BK channel activator with great research potential
By Farzana Islam on 08/17/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK 293

I have used NS1619 as the standard BK channel opener compound to study how its effect measures up to few other drugs known to have BK channel activation properties. Concentrations of 0.1 microM, 1 microM, 10 microM and 100 microM were made. NS1619 was dissolved in sterile DMSO. Absorbance given off by HEK 293 cells when treated by both NS1619 and test compounds were measured by flame AAS.

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