NPY 5RA972

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Cat.No. 3677 - NPY 5RA972 | C21H25N3O2 | CAS No. 439861-56-0
Description: Potent and selective NPY Y5 antagonist
Chemical Name: N-[4-Methyl-9-(1-methylethyl)-9H-carbazol-3-yl]-4-morpholinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent and selective neuropeptide Y Y5 receptor antagonist (IC50 values are 3.1, >10000, >10000 and >10000 nM for Y5, Y1, Y2 and Y4 receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant.

Compound Libraries

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Technical Data

M. Wt 351.44
Formula C21H25N3O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 439861-56-0
PubChem ID 9884833
InChI Key ZNFMHLDBJPAFEQ-UHFFFAOYSA-N
Smiles CC1=C(NC(N4CCOCC4)=O)C=CC3=C1C2=CC=CC=C2N3C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.45 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Block et al (2002) Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. J.Med.Chem. 45 3509 PMID: 12139462

Turnbull et al (2002) Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes 51 2441 PMID: 12145156

Morris et al (2007) Neuropeptide Y suppresses absence seizures in a genetic model primarily through effects on Y receptors. Eur.J.Neurosci. 25 1136 PMID: 17331209


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1 Citation for NPY 5RA972

Citations are publications that use Tocris products. Selected citations for NPY 5RA972 include:

Zhang et al (2015) Neuropeptide Y Stimulates Proliferation and Migration of Vascular Smooth Muscle Cells from Pregnancy Hypertensive Rats via Y1 and Y5 Receptors. PLoS One 10 e0131124 PMID: 26131716


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Literature in this Area

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